細(xì)胞在轉(zhuǎn)錄和翻譯遺傳信息的時候會產(chǎn)生一定的隨機(jī)性，這種隨機(jī)波動被稱為“噪音”，遺傳回路中的噪音可造成細(xì)胞功能和表型之間的差別,，因此得到越來越多的關(guān)注,。但是目前對這種噪音的來源以及它如何影響細(xì)胞的功能了解甚少,。
德克薩斯州立大學(xué)的John E.Ladbury 和Stefan T.Arold 的研究結(jié)果表明細(xì)胞噪音可能來自于蛋白質(zhì)與蛋白質(zhì)間的強烈相互作用（protein–protein interactions,，PPi），并揭示了這種內(nèi)部相互作用最終導(dǎo)致細(xì)胞信號通路的建立,。相關(guān)學(xué)術(shù)成果發(fā)表在近期的Cell子刊Trends in Biochemical and Science上,。研究人員表示，蛋白的多聚化或復(fù)合體形成,，蛋白濃度的變換以及對復(fù)雜信號的整合過程都可能產(chǎn)生噪音,。之所以能檢測到噪音，是因為細(xì)胞內(nèi)信號轉(zhuǎn)導(dǎo)的過程更偏向于一系列的概率事件的組合,，而不是直線型的傳播過程,。
癌癥的形成是與細(xì)胞信號網(wǎng)絡(luò)紊亂有關(guān)，因此,，理解了這種噪音信號對細(xì)胞的影響有可能對癌癥理論有更新的認(rèn)識,。（生物谷 Bioon.com ）
doi:10.1016/j.tibs.2012.01.001
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PMID:
Noise in cellular signaling pathways: causes and effects
John E. Ladbury, Stefan T. Arold
Noise caused by stochastic fluctuations in genetic circuits (transcription and translation) is now appreciated as a central aspect of cell function and phenotypic behavior. Noise has also been detected in signaling networks, but the origin of this noise and how it shapes cellular outcomes remain poorly understood. Here, we argue that noise in signaling networks results from the intrinsic promiscuity of proteinprotein interactions (PPIs), and that this noise has shaped cellular signal transduction. Features promoted by the presence of this molecular signaling noise include multimerization and clustering of signaling components, pleiotropic effects of gross changes in protein concentration, and a probabilistic rather than a linear view of signal propagation.
