據(jù)最新《蛋白質(zhì)組學(xué)研究雜志》報道,，意大利科學(xué)家完成的一項新研究發(fā)現(xiàn),，孤獨癥兒童的唾液中含有某些特別的復(fù)合物,。因此唾液檢測可以診斷出孤獨癥。
天主教圣心大學(xué)教授馬西姆·卡斯塔格諾拉等研究人員分析了27名自閉癥(泛自閉癥障礙)兒童和23名健康兒童的唾液樣本,。研究焦點集中于某些較小蛋白和縮氨酸,。結(jié)果發(fā)現(xiàn)，三分之二的自閉癥患兒至少有一種唾液縮氨酸與健康孩子不同,。
研究人員表示,，唾液縮氨酸分析將有助于識別出有自閉癥傾向的人群。（生物谷Bioon.com）
生物谷推薦原始出處：
J. Proteome Res,，DOI: 10.1021/pr8004088,，Massimo Castagnola，F(xiàn)iorella Gurrieri
Hypo-Phosphorylation of Salivary Peptidome as a Clue to the Molecular Pathogenesis of Autism Spectrum Disorders
RP-HPLC-ESI-MS profile of naturally occurring salivary peptides of subjects with autistic spectrum disorder [ASD; N = 27: 12 with diagnosis of autism, 1 with diagnosis of Asperger, 14 with diagnosis of pervasive developmental disorders not otherwise specified (PDD-NOS)] was compared to that of age-matched controls with the goal of identifying differences that could turn out to become hallmarks of at least a subgroup of ASD individuals. Phosphorylation level of four specific salivary phospho-peptides, namely statherin, histatin 1 (both, p < 0.0001) and acidic proline-rich proteins (both entire and truncated isoforms) (p < 0.005) was found significantly lower in autistic patients, with hypo-phosphorylation of at least one peptide observed in 18 ASD subjects (66%). Developmental scale assessment (Griffith or WISC-R) carried out on 14 ASD subjects highlighted a normal to borderline cognitive development in 10 of them, all included in the hypo-phosphorylated group. Phosphorylation of salivary peptides involves a Golgi casein kinase common to many organs and tissues, CNS included, whose expression seems to be synchronized during fetal development. Hypo-phosphorylation of salivary peptides suggests potential asynchronies in the phosphorylation of other secretory proteins, which could be relevant in CNS development either during embryonic development or in early infancy. These results suggest that analysis of salivary phospho-peptides might help to discriminate a considerable subgroup of ASD patients.
