一篇非常好的文章。作者結(jié)合生物芯片數(shù)據(jù)分析工作,，探討了現(xiàn)在功能基因組研究中所面臨的統(tǒng)計(jì)學(xué)問題,，這既是一篇綜述,，也是一篇指南性的文章,，下面是文章的前言,。
On February 12, 2001 the Human Genome Project announced that it had assembled a draft physical map of the human genome - the genetic blueprint for a human being. Now the challenge is to annotate this map, by understanding the functions of genes and their interplay with proteins and the environment to create complex, dynamic living systems. This is the goal of functional genomics. Recent technological advances enable biomedical investigators to observe the genome of entire organisms in action by simultaneously measuring the level of activation of thousands of genes under the same experimental conditions. This technology, known as microarrays, provides today unparalleled discovery opportunities and it is reshaping biomedical sciences. One of the main aspects of this revolution is the introduction of heavily quantitative data-analytical methods in biomedical research. This paper reviews the foundations of this technology and describes the statistical challenges posed by the analysis of microarray data.
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