近日，中科院上海生科院營養(yǎng)所賀林研究組與加迪夫大學(xué),、牛津大學(xué),、劍橋大學(xué)、上海交通大學(xué),、斯坦福大學(xué)等學(xué)術(shù)機構(gòu)的科學(xué)家合作,，首次發(fā)現(xiàn)ZNF804A基因與精神分裂癥存在強烈的相關(guān)性,，研究論文"Identification of loci associated with schizophrenia by genome-wide association and follow-up"發(fā)表在《自然—遺傳學(xué)》（Nature Genetics）上，引起國際學(xué)術(shù)界較大反響,。
精神分裂癥是一種極其嚴(yán)重且愈后不良的重性精神疾病,，患病率約為1%，由于精神分裂癥的病因復(fù)雜,，遺傳學(xué)者一直沒有發(fā)現(xiàn)確鑿的致病基因和致病突變。營養(yǎng)所賀林院士領(lǐng)導(dǎo)的研究組與加迪夫大學(xué),、牛津大學(xué),、劍橋大學(xué)、上海交通大學(xué),、斯坦福大學(xué)等學(xué)術(shù)機構(gòu)進行了國際合作研究,，運用最新的全基因組關(guān)聯(lián)分析技術(shù)，通過對479名精神分裂癥患者和2,937名正常對照的全基因組關(guān)聯(lián)分析,，以及基于16,726樣品的重復(fù)驗證和薈萃分析結(jié)果,，首次發(fā)現(xiàn)ZNF804A基因與精神分裂癥強烈的相關(guān)性（P<=1.61x10-7）。ZNF804A基因作為精神分裂癥易感基因被發(fā)現(xiàn),，開創(chuàng)了精神疾病遺傳學(xué)研究的全基因組關(guān)聯(lián)分析時代,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics，doi:10.1038/ng.201,，Michael C O'Donovan, Michael J Owen
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Michael C O'Donovan1, Nicholas Craddock1, Nadine Norton1, Hywel Williams1, Timothy Peirce1, Valentina Moskvina1, Ivan Nikolov1, Marian Hamshere1, Liam Carroll1, Lyudmila Georgieva1, Sarah Dwyer1, Peter Holmans1, Jonathan L Marchini2, Chris C A Spencer2, Bryan Howie2, Hin-Tak Leung3, Annette M Hartmann4, Hans-Jürgen Möller5, Derek W Morris6, YongYong Shi7, GuoYin Feng8, Per Hoffmann9, Peter Propping10, Catalina Vasilescu9, Wolfgang Maier11, Marcella Rietschel12, Stanley Zammit1, Johannes Schumacher13, Emma M Quinn6, Thomas G Schulze13, Nigel M Williams1, Ina Giegling4, Nakao Iwata14,15, Masashi Ikeda14,15, Ariel Darvasi16, Sagiv Shifman16, Lin He7,17, Jubao Duan18,19, Alan R Sanders18,19, Douglas F Levinson20, Pablo V Gejman18,19, Molecular Genetics of Schizophrenia Collaboration21, Sven Cichon9,10, Markus M Nöthen9,10, Michael Gill6, Aiden Corvin6, Dan Rujescu4, George Kirov1 & Michael J Owen1
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).
