生物谷Bioon.com 訊 ,，據(jù)新華網(wǎng)最新報(bào)道稱,，一個(gè)日本研究小組在2日的英國(guó)《自然·遺傳學(xué)》雜志網(wǎng)絡(luò)版上報(bào)告說(shuō)，在對(duì)日本4000余名前列腺癌患者進(jìn)行全基因組分析后,，研究人員發(fā)現(xiàn),，與前列腺癌發(fā)病相關(guān)的5個(gè)單核苷酸多態(tài)性（SNP）可能為日本人所獨(dú)有。
單核苷酸多態(tài)性主要是指在基因組水平上由單個(gè)核苷酸變異引起的DNA（脫氧核糖核酸）序列多態(tài)性,。
由日本理化研究所和東京大學(xué)等機(jī)構(gòu)組成的研究小組,，對(duì)日本4584名前列腺癌患者和8801名健康人進(jìn)行了全基因組對(duì)照分析。他們發(fā)現(xiàn),，在此前科研人員發(fā)現(xiàn)的與歐美人患前列腺癌相關(guān)的31個(gè)單核苷酸多態(tài)性中,，有19個(gè)與日本人患該病有關(guān)，另外12個(gè)則沒(méi)有在日本患者身上發(fā)現(xiàn),。此外,，研究人員還新發(fā)現(xiàn)了與日本人患前列腺癌有強(qiáng)烈關(guān)聯(lián)的5個(gè)單核苷酸多態(tài)性,。
前列腺癌是世界上發(fā)病率較高的癌癥之一。在日本,，隨著生活方式不斷西化和人口老齡化,，前列腺癌患者人數(shù)迅速增加。據(jù)統(tǒng)計(jì),，2008年日本約有1萬(wàn)人死于前列腺癌,。
日本理化研究所和東京大學(xué)2日聯(lián)合發(fā)布的新聞公報(bào)說(shuō)，這項(xiàng)成果揭示了不同人種和民族患前列腺癌的遺傳差異,，有助于進(jìn)一步揭示前列腺癌發(fā)病機(jī)理,，建立適用于日本人的前列腺癌風(fēng)險(xiǎn)評(píng)估體系。(生物谷Bioon.com)
生物谷推薦原文出處：
Nature Genetics doi:10.1038/ng.635
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Ryo Takata1,2, Shusuke Akamatsu1,3, Michiaki Kubo4, Atsushi Takahashi5, Naoya Hosono4, Takahisa Kawaguchi6, Tatsuhiko Tsunoda6, Johji Inazawa7, Naoyuki Kamatani5, Osamu Ogawa3, Tomoaki Fujioka2, Yusuke Nakamura8 & Hidewaki Nakagawa1
Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 × 10?7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability PGC = 3.9 × 10?18), GPRC6A/RFX6 (PGC = 1.6 × 10?12), 13q22 (PGC = 2.8 × 10?9), C2orf43 (PGC = 7.5 × 10?8) and FOXP4 (PGC = 7.6 × 10?8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.
