生物谷報(bào)道：美國(guó)麥迪遜威斯康辛大學(xué)的華裔科學(xué)家張張?zhí)K俊(譯音,，Su-Chun Zhang)領(lǐng)導(dǎo)的一個(gè)研究小組，日前研究出一項(xiàng)“食譜”――把人類胚胎干細(xì)胞引入人類細(xì)胞之中,，就可在人體內(nèi)激活某些細(xì)胞的生長(zhǎng),，從而達(dá)到治病的功效。
張?zhí)K俊領(lǐng)導(dǎo)的小組研究了兩年,，最后找出這張“食譜”,。他們的研究是將干細(xì)胞引入人的腦細(xì)胞中，因?yàn)槟X細(xì)胞具有控制人體動(dòng)作的功能,。
據(jù)美國(guó)世界新聞網(wǎng)報(bào)道,，科學(xué)家指出，張?zhí)K俊的發(fā)現(xiàn)有兩項(xiàng)重要意義：第一,，科學(xué)家研究了動(dòng)物干細(xì)胞很長(zhǎng)時(shí)間,，但始終無(wú)法找到引導(dǎo)干細(xì)胞的辦法，張?zhí)K俊的發(fā)現(xiàn)證明,，借著把干細(xì)胞引進(jìn)人類的一些細(xì)胞中,，就可產(chǎn)生引導(dǎo)干細(xì)胞的作用。哈佛大學(xué)神經(jīng)科學(xué)家?jiàn)W爾·艾薩克森指出,，張?zhí)K俊的發(fā)現(xiàn)有助科學(xué)家把過(guò)去25年研究動(dòng)物干細(xì)胞所得的資料轉(zhuǎn)化為人類干細(xì)胞的資料,，因此貢獻(xiàn)很大。
第二,，張?zhí)K俊的研究還發(fā)現(xiàn),，“食譜”是否成功――即是否能夠引導(dǎo)干細(xì)胞，除了“食譜”組成的元素(例如不同的干細(xì)胞和不同的人類細(xì)胞)和數(shù)量外,，還必須在適當(dāng)時(shí)間內(nèi)進(jìn)行調(diào)制,。時(shí)間性的掌握極為重要?？茖W(xué)家說(shuō),，這項(xiàng)發(fā)現(xiàn)很重要，因?yàn)槿梭w自有生理時(shí)鐘,，不同時(shí)間有不同狀態(tài),，張?zhí)K俊的發(fā)現(xiàn)，使科學(xué)家知道,，必須留意時(shí)間,，不再像以前那樣，以為隨時(shí)都可以進(jìn)行實(shí)驗(yàn),。
張?zhí)K俊研究方向：
The remarkable developmental potential and replicative capacity of human embryonic stem (ES) cells promise an almost unlimited supply of specific cell types for transplant therapies. Key to this powerful application is the differentiation and isolation of specific cell lineages from pluripotent ES cells. Our laboratory focuses on the neural pathway of ES cell differentiation. We have established an in vitro model of ES cell differentiation to neuroepithelial cells, which are organized in a neural tube-like structure. Using this system, we ask what controls neuroepithelial specification from ES cells and how the neuroepithelia organize into a neural tube. We will then examine whether a regionally specific neural cell type can be patterned in vitro by dorso-ventral and rostro-caudal signals. We are particularly interested in the ventral neural cell types, e.g., retinal ganglion neurons, midbrain dopamine neurons, spinal cord motoneurons and myelinating oligodendrocytes. The ES cell-derived neural cells will be evaluated for their therapeutic potential in animal models including monkey models for spinal cord injury (neuroepithelia) and neurodegenerative disorders such as Parkinson's disease (dopamine neurons), ALS (motoneurons) and MS (oligodendrocytes).
Su-Chun Zhang
M.D., Wenzhou Medical College
PhD, University of Saskatchewan
Assistant Professor of Anatomy and Neurology
Contact Information
Waisman Center
UW-Madison
1500 Highland Avenue
Madison, WI 53705
608-265-2543
608-263-5267 (fax)
E-mail: [email protected]
Web: http://www.news.wisc.edu/packages/stemcells/
