每年有超過六萬名美國人罹患淋巴瘤。加州大學(xué)洛杉磯分校的研究人員發(fā)現(xiàn)了與淋巴瘤有關(guān)的基因,，將有助于開發(fā)出治療這種疾病的新路徑,，他們辨認(rèn)出一些基因不活化時，會導(dǎo)致B 細(xì)胞非霍金奇氏淋巴瘤(NHL),。
這些基因缺陷可能也與其它癌癥的形成有關(guān),，因?yàn)樗鼈儠拐５哪[瘤抑制基因不活化。
這個研究團(tuán)隊由Michael Teitell醫(yī)師領(lǐng)軍,，并接受The Leukemia & Lymphoma Society的資助,，利用經(jīng)過遺傳設(shè)計的小鼠準(zhǔn)確地模仿人類B細(xì)胞癌。
之前發(fā)表的研究,，從NHL患者的癌細(xì)胞辨認(rèn)出經(jīng)常發(fā)生異常的基因缺陷,，因此發(fā)現(xiàn)了當(dāng)TCL1 基因及其它相關(guān)的基因發(fā)生異常時，可能導(dǎo)致小鼠發(fā)生NHL,。
現(xiàn)在，他們利用一種強(qiáng)大的遺傳技術(shù)--限制性標(biāo)志的基因掃描(RLGS),，發(fā)現(xiàn)這些與TCL1 基因一起導(dǎo)致NHL的基因,。這些基因在淋巴瘤中，會發(fā)生DNA過甲基化而造成缺陷,。
這項(xiàng)突破性的研究發(fā)表于2007 年1月29 日的Oncogene中,，研究結(jié)果有助于研發(fā)治療NHL的新藥物。
(資料來源 : Bio.com)
英文原文：
UCLA Researchers Discover Genes Linked to Lymphoma
Jan 30 2007, 12:37 PM EST
GEN News Highlights
Researchers at the University of California Los Angeles identified genes that, when inactivated, help cause B-cell non-Hodgkin's lymphoma (NHL). These genetic defects may also be involved in promoting the formation of other cancers since they can inactivate normal tumor-suppressing gene activities in a range of cell types.
The team used genetically engineered mice to accurately mimic human B-cell cancers. They had previously identified frequent genetic abnormalities in cancer cells from NHL patients—namely defects in the TCL1 gene—and showed that TCL1 abnormalities can cause NHL in mice when accompanied by additional genetic defects. Now, they have found some of these cancer collaborators.
Michael Teitell, M.D., Ph.D., and his team used restriction landmark genomic scanning (RLGS) to find genes that work with abnormal TCL1 to promote lymphoma formation. These genes are inactivated in lymphomas by DNA hypermethylation.
The research, published in the January 29, 2007, issue of Oncogene, may help in the development of new targeted drugs for NHL patients.The study was funded by The Leukemia & Lymphoma Society.
