生物谷報道：最新的《Science》雜志報道的一項新研究發(fā)現(xiàn)，一個原來已知的調(diào)節(jié)神經(jīng)元存活的蛋白質(zhì)看來也在肝臟修復(fù)中起重要作用。這些發(fā)現(xiàn)提出,，名為p75NTR的蛋白質(zhì)也許是控制肝臟疾病藥物的一個有用的靶標(biāo)。
由于so-hepatocyte增殖和形成新組織的能力,，肝臟能非凡地自我再生,。這個過程需要肝星狀細(xì)胞來產(chǎn)生支持肝細(xì)胞增殖的基質(zhì)。生長因子p75NTR在神經(jīng)系統(tǒng)發(fā)育過程中以及受損后表達(dá),，其表達(dá)也在人與動物模型身上造成肝硬化的增加,。為了更多地了解這個生長因子在肝臟再生中的作用，Melissa Passino和同事制造了一個缺少該蛋白質(zhì)的小鼠家系,。他們報告說,，這些小鼠制造較少的肝細(xì)胞。p75NTR看來激活肝星狀細(xì)胞,，誘導(dǎo)它們分化成其它生長因子和肝細(xì)胞需要的細(xì)胞外基質(zhì),，所以p75NTR是肝臟修復(fù)過程中兩個關(guān)間細(xì)胞類型間的一個重要的連接。
原文出處：
Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75NTR, Melissa A. Passino, Ryan A. Adams, Shoana L. Sikorski, and Katerina Akassoglou
Science 30 March 2007 315: 1764 [DOI: 10.1126/science.315.5820.1764a] (in This Week in Science)
Summary » PDF »
作者簡介：
Katerina Akassoglou, Ph.D.
Assistant Professor
Department of Pharmacology
University of California, San Diego
EDUCATION
1998-2001 Postdoc
State University of New York at Stony Brook
The Rockefeller University
1994-1998 Ph.D. in Neurobiology
University of Athens, Athens, Greece
1990-1994 B.Sc. in Biology (First Class Honors)
University of Athens
Athens, Greece
POSITIONS
2003-Today Assistant Professor
Department of Pharmacology, UCSD
La Jolla, CA
2002-2003 Research Associate
Molecular Neurobiology Program
Skirball Institute of Biomolecular Medicine
New York University Medical Center
New York, NY
2001-2002 Research Associate
The Rockefeller University
New York, NY
相關(guān)基因：
Ngfr
Official Symbol: Ngfr and Name: nerve growth factor receptor (TNFR superfamily, member 16) [Mus musculus]
Other Aliases: RP23-67E18.6, LNGFR, Tnfrsf16, p75, p75NGFR, p75NTR
Other Designations: p75 neurotrophin receptor
Chromosome: 11; Location: 11 55.6 cM
GeneID: 18053
