生物谷報道：骨質疏松癥（Osteoporosis）是一種最常見的骨頭代謝性的疾病,，它會造成持續(xù)性的骨密度減少,，造成骨頭脆弱,；但是同時骨頭的礦物質和有機質的組成比例仍然維持不變,。由于骨密度較低,，骨頭強度較弱，所以容易造成骨折,。在美國,，每年大約有2000萬人受到骨質疏松癥的影響，其中有130萬人造成骨折,。
在正常的骨頭中,，骨頭的形成與再吸收大致上達成一個動態(tài)的平衡；但是在骨質疏松癥的病人,，再吸收的速度大于形成的速度,，造成骨頭質量的減少。
雖然女性發(fā)生骨質疏松癥的比率比男性高出四倍,，但是每12名男性中,，還是有一人會發(fā)生骨質疏松癥。
骨質疏松癥的潛在原因很多,，一般認為女性的骨質疏松癥主要是由于更年期過后雌性激素含量減少所致,。
根據(jù)一篇由華盛頓大學醫(yī)學院發(fā)表的新研究指出,，男性體內的雌性激素含量過低也會增加他們發(fā)生骨質疏松癥的風險,。
睪固酮使男性骨頭更大且更厚實,，但雌性激素卻是為持骨頭礦物質含量的關鍵激素。研究人員也觀察了其它因素與骨質密度間的關連性,，包括抽煙,、飲酒量、每日鈣攝取量和身體質量指數(shù)(BMI),。結果只發(fā)現(xiàn)BMI與骨頭密度有關,，BMI較高的男性有較高的骨頭密度。
(資料來源 : Bio.com)
英文原文鏈接：
原始出處:
Calcified Tissue International,，Volume 80, Number 4 / 2007年4月
10.1007/s00223-007-9014-4
Estrogen Metabolism Modulates Bone Density in Men
N. Napoli1, 3 , R. Faccio2, V. Shrestha3, S. Bucchieri4, G. Battista Rini4 and R. Armamento-Villareal1
(1) Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
(2) Department of Orthopedics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
(3) Department of Medicine, University of Palermo, Via del Vespro 141, 90127, Palermo, Italy
(4) Department of Medicine, St. Luke’s Hospital, Chesterfield, MO, USA
Received: 26 June 2006 Accepted: 9 January 2007 Published online: 4 April 2007
Abstract
Abstract Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 ± 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16α-hydroxyestrone (16αOHE1) and estriol (E3), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16αOHE1 had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2−hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16αOHE1, FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16αOHE1 and E3 levels are associated with high BMD at the proximal femur, and 16αOHE1 appears to be a major determinant of BMD among the metabolites evaluated.
Keywords Male osteoporosis - Estrogen metabolism - Bone mineral density
