生物谷報(bào)道：美國(guó)辛辛那提大學(xué)的研究人員發(fā)現(xiàn),，用患者自身的血小板制成的一種濃縮凝聚來(lái)治療皮膚傷口能夠加快傷口的愈合。這項(xiàng)研究結(jié)果發(fā)表在Archives of Facial Plastic Surgery雜志上,。
這項(xiàng)研究的領(lǐng)導(dǎo)者,、耳鼻喉科專家David Hom博士與面部整形醫(yī)生一同完成了這項(xiàng)研究。研究組發(fā)現(xiàn),，與對(duì)照的抗生素藥膏相比,，使用患者自身的血小板凝膠治療皮膚創(chuàng)傷的恢復(fù)速更快。
研究人員對(duì)21－58歲的8名志愿者（4男4女）進(jìn)行了研究：先在志愿者兩條大腿上制造皮膚創(chuàng)傷（直徑4mm）,，然后用血小板凝膠治療一條腿上的創(chuàng)傷,，而另一條腿上的創(chuàng)傷則用抗生素藥膏處理。在接下來(lái)的六個(gè)月里,，研究人員對(duì)傷口愈合狀況進(jìn)行跟蹤調(diào)查,。
跟蹤結(jié)果顯示，在一個(gè)為期42天的周期里,，研究人員發(fā)現(xiàn)用血小板凝膠處理的皮膚創(chuàng)傷比抗生素處理的皮膚創(chuàng)傷明顯愈合較快,。
分析顯示，生長(zhǎng)因子在傷口愈合中發(fā)揮重要作用,，對(duì)用血小板凝膠處理的傷口部位,，其促進(jìn)愈合的生長(zhǎng)因子含量也明顯增加了。
原始出處:
Arch Facial Plast Surg. 2007;9:174-183.
The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds
David B. Hom, MD; Bradley M. Linzie, MD; Trevor C. Huang, PhD
Objective To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers.
Methods A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylin-eosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.
Results Over a 42-day period, the APG-treated sites had statistically increased wound closure compared with controls by visual clinical assessment and by digital planimetry photographic measurements (P.02). On day 17, the percentage of closure was 81.1% ± 2.5% (mean ± SE) for the APG-treated sites and 57.2% ± 5.9% for the control sites. Also, the APG wound closure velocities were significantly faster than those of the controls (P = .001). Histologically, over time, the APG-treated sites had similar cellularity, cellular replication, granulation tissue, vascularity, and epithelialization compared with controls. However, when the platelet count in the gel was more than 6 times the baseline intravascular platelet count in some subjects, epithelialization and granulation formation appeared 3 days earlier in the APG-treated group. Furthermore, in vitro testing of supplemental APG showed increased endothelial cell proliferation compared with controls (P<.04).
Conclusion This pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness dermal wounds in healthy individuals.
Trial Registration clinicaltrials.gov Identifier: NCT00199992
Author Affiliations: Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Minnesota School of Medicine and Hennepin County Medical Center (Dr Hom), Department of Pathology, Hennepin County Medical Center (Dr Linzie), and Medtronic Inc (Dr Huang), Minneapolis, Minn. Dr Hom is now with the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
