生物谷報(bào)道：炎癥性腸道疾病（inflammatory bowel disease, IBD）是一大類疾病,，其中包括克羅恩?。–rohn’s disease）和潰瘍性結(jié)腸炎。它們屬于多基因疾病,，并且還與各種不同的環(huán)境因素有關(guān),。盡管如此復(fù)雜，但研究人員在揭示其病因方面還是取得了相當(dāng)大的進(jìn)展,。Ramnik Xavier 和 Daniel Podolsky對這一領(lǐng)域的最新進(jìn)展做了綜述,，其中包括一系列易感基因的發(fā)現(xiàn)以及重要環(huán)境因素的識別。IBD的遺傳學(xué)研究表明,，表皮屏障功能,、以及先天和后天免疫在這類疾病的發(fā)病中發(fā)揮著作用。關(guān)鍵環(huán)境因素包括能夠破壞免疫功能的共生細(xì)菌,。在了解IBD病因方面所取得的進(jìn)展表明,，我們也有可能對心臟病、糖尿病和其他多基因疾病的致病因素進(jìn)行類似的解析
原始出處:
Nature 448, 427-434 (26 July 2007) | doi:10.1038/nature06005
Unravelling the pathogenesis of inflammatory bowel disease
R. J. Xavier1,2 & D. K. Podolsky1
Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.
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Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, and,
Center for Computational and Integrative Biology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Correspondence to: D. K. Podolsky1 Correspondence should be addressed to D.K.P. (Email: [email protected]).
