生物谷：癌細(xì)胞的恒久生命與導(dǎo)致人死亡的衰老過(guò)程看起來(lái)似乎是相對(duì)立的,。但令人吃驚的是，癌細(xì)胞和衰老過(guò)程的生物學(xué)基礎(chǔ)卻是相合的,?；蚪M不穩(wěn)定、端粒異常和自噬作用等在癌癥和衰老的相關(guān)研究中成為了熱點(diǎn)問(wèn)題,。
研究人員已經(jīng)在腫瘤發(fā)生與細(xì)胞衰老之間發(fā)現(xiàn)了聯(lián)系,。線粒體代謝似乎可以對(duì)這兩個(gè)問(wèn)題進(jìn)行合理解釋,。Finkel等人從歷史角度向我們介紹了癌癥和衰老的共同生物學(xué)基礎(chǔ)：從第一次意識(shí)到人類(lèi)癌細(xì)胞—Hela細(xì)胞—在培養(yǎng)中有可能繼續(xù)分裂一直談到系統(tǒng)生物學(xué)方法的問(wèn)世,。
圖：The potential interplay between stem cells, stress, ageing and cancer
原始出處:
Nature 448, 767-774 (16 August 2007) | doi:10.1038/nature05985
The common biology of cancer and ageing
Toren Finkel1, Manuel Serrano2 & Maria A. Blasco2
At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic—and some say unethical—events that unfolded more than half a century ago. Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer.
Cardiology Branch, NIH, NHLBI, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, Maryland 20892, USA
Spanish National Cancer Research Center (CNIO) 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
Correspondence to: Toren Finkel1 Correspondence should be addressed to T.F. (Email: [email protected]).
