生物谷報道：英國醫(yī)學研究委員會科學家16日在science發(fā)表論文,，報道了關于生物鐘最新的研究結(jié)果,。
c-AMP作為體內(nèi)一種重要的信號分子在視交叉上核(suprachiasmatic nuclei, SCN)中也起到了關鍵的作用。而人體生物鐘就位于大腦中的視交叉上核,。 科學家表示,，對于因航空旅行、倒班或疾病打亂了睡眠規(guī)律的人,，控制c-AMP生物路徑的藥物能夠重新設置他們的生物鐘,。該委員會已就此項技術提出專利申請。 生理節(jié)律混亂日益成為慢性疾病的重要成因,。如果能找到控制生物鐘的方法,，也許就能知道在生物鐘紊亂時如何進行調(diào)節(jié)。（生物谷www.bioon.com）
生物谷推薦原始出處：
Science 16 May 2008,，DOI: 10.1126/science.1152506
cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker
John S. O'Neill,1* Elizabeth S. Maywood,1 Johanna E. Chesham,1 Joseph S. Takahashi,2 Michael H. Hastings1
The mammalian circadian clockwork is modeled as transcriptional and posttranslational feedback loops, whereby circadian genes are periodically suppressed by their protein products. We show that adenosine 3',5'-monophosphate (cAMP) signaling constitutes an additional, bona fide component of the oscillatory network. cAMP signaling is rhythmic and sustains the transcriptional loop of the suprachiasmatic nucleus, determining canonical pacemaker properties of amplitude, phase, and period. This role is general and is evident in peripheral mammalian tissues and cell lines, which reveals an unanticipated point of circadian regulation in mammals qualitatively different from the existing transcriptional feedback model. We propose that daily activation of cAMP signaling, driven by the transcriptional oscillator, in turn sustains progression of transcriptional rhythms. In this way, clock output constitutes an input to subsequent cycles.
1 Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
2 Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208–3520, USA.
* Present address: Center for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh EH9 3JU, UK.
