日本東京大學(xué)與理化學(xué)研究所的研究小組最近的一項研究結(jié)果顯示,B型、AB型血女性與A型,、O型血女性相比不容易患貧血,。
該小組通過對大約1.5萬人的遺傳因子進(jìn)行分析而得出的這一研究成果8日被發(fā)表在了美國的科學(xué)雜志《自然遺傳學(xué)》電子版上,。研究顯示,是否易患一些生活常見疾病與人體對藥物的適應(yīng)性都會因人而異,這是由于在構(gòu)成人體DNA的30億對堿基當(dāng)中有1000萬對可能會出現(xiàn)變異所引起的。
研究小組使用高性能計算機(jī)對10類病患者的遺傳因子數(shù)據(jù)進(jìn)行了分析,其結(jié)果證實人體的46條染色體中的基因變異除了會影響尿酸之外,還會影響到紅血球,、白血球、血小板等一些血液化驗項目的數(shù)值,。
其中,以紅血球與血型之間的關(guān)系來看,B型、AB型血的女性與A型,、O型血女性相比患有貧血的幾率降低了21%。研究人員認(rèn)為,這是由于在形成B型,、AB型的遺傳因子上出現(xiàn)基因變異會使血色素增高從而減少患貧血的幾率,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics 7 February 2010 | doi:10.1038/ng.531
Genome-wide association study of hematological and biochemical traits in a Japanese population
Yoichiro Kamatani1,2, Koichi Matsuda1, Yukinori Okada3, Michiaki Kubo4, Naoya Hosono4, Yataro Daigo1,2, Yusuke Nakamura1,5 & Naoyuki Kamatani3
We report genome-wide association studies for hematological and biochemical traits from ~14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 × 10?8). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.
1 Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
2 Department of Medical Genome Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan.
3 Laboratory for Statistical Analysis, Kanagawa, Japan.
4 Laboratory for Genotyping Development, Kanagawa, Japan.
5 Center for Genomic Medicine, RIKEN, Kanagawa, Japan.
