一個(gè)由德國(guó)科學(xué)家領(lǐng)導(dǎo)的國(guó)際研究小組21日宣布,，他們發(fā)現(xiàn)了一種會(huì)大大增加心房纖顫（房顫）風(fēng)險(xiǎn)的基因,。
這項(xiàng)研究由德國(guó)慕尼黑大學(xué),、亥姆霍茲慕尼黑中心和美國(guó)馬薩諸塞州綜合醫(yī)院等50多個(gè)機(jī)構(gòu)參與,。研究人員對(duì)1335名沒有其他心臟疾病的所謂孤立性房顫患者和一萬(wàn)多名健康人的基因組進(jìn)行了比較分析,，最終發(fā)現(xiàn)會(huì)明顯增加房顫風(fēng)險(xiǎn)的KCNN3基因。
研究人員發(fā)現(xiàn),，該基因參與影響心臟起搏的一種鉀通道的合成,。研究人員說(shuō)，根據(jù)這一特點(diǎn),，將來(lái)可研發(fā)專門對(duì)這種鉀通道發(fā)生作用的新藥物,，以糾正心臟起搏的失調(diào)。此外,，研究人員還希望這一成果能幫助預(yù)測(cè)個(gè)人罹患房顫的風(fēng)險(xiǎn),。
該研究成果已發(fā)表在英國(guó)《自然·遺傳學(xué)》雜志網(wǎng)絡(luò)版上。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics 21 February 2010 | doi:10.1038/ng.537
Common variants in KCNN3 are associated with lone atrial fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an increased heritability of AF. We report a meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (referents). Cases were obtained from the German AF Network, Heart and Vascular Health Study, the Atherosclerosis Risk in Communities Study, the Cleveland Clinic and Massachusetts General Hospital. We identified an association on chromosome 1q21 to lone AF (rs13376333, adjusted odds ratio = 1.56; P = 6.3 × 10?12), and we replicated this association in two independent cohorts with lone AF (overall combined odds ratio = 1.52, 95% CI 1.40–1.64; P = 1.83 × 10?21). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization.
