日本東京理科大學(xué)研究人員日前發(fā)現(xiàn),，胚胎發(fā)育初期,，細(xì)胞間質(zhì)分泌的一種蛋白質(zhì)能促進(jìn)胚胎分化出組織和器官。這項(xiàng)研究成果已刊登在新一期美國(guó)《國(guó)家科學(xué)院學(xué)報(bào)》（PNAS）網(wǎng)絡(luò)版上,。
一般來說,，由受精卵發(fā)育成的初期胚胎，是由上皮組織和結(jié)締組織組成的,。上皮細(xì)胞與結(jié)締組織中的間質(zhì)一方面會(huì)相互作用,，一方面會(huì)分化成心臟和腎臟等器官。不過,，兩者間相互作用的具體機(jī)制一直不清楚,。
日本研究人員通過實(shí)驗(yàn)鼠研究發(fā)現(xiàn)，在上述過程中,，細(xì)胞間質(zhì)分泌的“卵泡抑素樣因子1”發(fā)揮著關(guān)鍵作用,。
在胚胎發(fā)育初期，如果出現(xiàn)異常,，就會(huì)導(dǎo)致胎兒畸形或出現(xiàn)癌變,。上述研究發(fā)現(xiàn)了胚胎發(fā)育中胚胎內(nèi)部相互作用的部分機(jī)制,，將有助于進(jìn)一步了解胎兒發(fā)育異常等病因。(生物谷Bioon.com)
生物谷推薦原文出處：
PNAS doi: 10.1073/pnas.0909501107
Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium
Tomohiro Umezu, Hiromi Yamanouchi, Yusuke Iida, Masataka Miura, and Yasuhiro Tomooka1
Mesenchyme is generally believed to play critical roles in “secondary induction” during organogenesis. Because of the complexity of tissue interactions in secondary inductions, however, little is known about the precise mechanisms at the cellular and molecular levels. We have demonstrated that, in mouse oviductal development, the mesenchyme determines the fate of undetermined epithelial cells to become secretory or cilial cells. We have established a model for studying secondary induction by establishing clonal epithelial and mesenchymal cell lines from perinatal p53?/? mouse oviducts. The signal sequence trap method collected candidate molecules secreted from mesenchymal cell lines. Naive epithelial cells exposed to Follistatin-like-1 (Fstl1), one of the candidates, became irreversibly committed to expressing a cilial epithelial marker and differentiated into ciliated cells. We concluded that Fstl1 is one of the mesenchymal factors determining oviductal epithelial cell fate. This is a unique demonstration that the determination of epithelial cell fate is induced by a single diffusible factor.
