一項(xiàng)研究說,，雙酚A能導(dǎo)致實(shí)驗(yàn)室線蟲的不育和胚胎死亡,。人們長久以來爭(zhēng)論雙酚A是否導(dǎo)致了一大批疾病，包括心臟病,、糖尿病和流產(chǎn),，這種物質(zhì)廣泛見于塑料，用于大多數(shù)食品與飲料的包裝中,。
美國的一些州已經(jīng)在兒童用品中禁用了這種化學(xué)物質(zhì),，但是幾乎每個(gè)人都會(huì)接觸到它。Patrick Allard 和Monica P. Colaiacovo測(cè)試了雙酚A對(duì)于秀麗隱桿線蟲（Caenorhabditis elegans）的精子和卵子從它們的前體中產(chǎn)生出來的細(xì)胞過程的影響,。秀麗隱桿線蟲是分子研究的一種實(shí)驗(yàn)?zāi)Ｌ亍?/p>
這組作者發(fā)現(xiàn),，雙酚A削弱了性細(xì)胞前體的特定DNA修復(fù)過程，已知它們對(duì)于精子和卵子的形成具有關(guān)鍵作用,。此外,，接觸雙酚A還會(huì)破壞染色體完整性、觸發(fā)細(xì)胞的損傷監(jiān)測(cè)系統(tǒng),，并導(dǎo)致細(xì)胞死亡,。這組作者發(fā)現(xiàn)，盡管對(duì)照組看上去正常,，接觸了雙酚A的卵細(xì)胞前體中出現(xiàn)瓦解,、破碎和聚集的染色體，最終導(dǎo)致了胚胎死亡和后代數(shù)量的下降,。這組作者說,，這些發(fā)現(xiàn)提示了雙酚A對(duì)人類生殖的影響的一種可能的機(jī)制。（生物谷Bioon.com）
生物谷推薦英文摘要：
PNAS doi: 10.1073/pnas.1010386107
Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities
Patrick Allard and Monica P. Colaiácovo1
Department of Genetics, Harvard Medical School, Boston, MA 02115
Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice, BPA exposure disrupts the process of meiosis; however, analysis of the affected molecular pathways is lagging and has been particularly challenging. Here we show that exposure of the nematode Caenorhabditis elegans to BPA, at internal concentrations consistent with mammalian models, causes increased sterility and embryonic lethality. BPA exposure results in impaired chromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression. BPA carries an anti-estrogenic activity in the germline and results in germline-specific down-regulation of DSBR genes, thereby impairing maintenance of genomic integrity during meiosis. C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis.
