植物的發(fā)育模式部分依賴于局部生長(zhǎng)和定向生長(zhǎng)。局部生長(zhǎng)由植物生長(zhǎng)激素調(diào)控,，定向生長(zhǎng)由細(xì)胞微管骨架管調(diào)控。加州理工學(xué)院的Marcus Heisler及其同事發(fā)現(xiàn),，當(dāng)擬南芥細(xì)胞壁受到機(jī)械震動(dòng)時(shí),，其莖尖微管的生長(zhǎng)發(fā)育顯示出脅迫模式。為驗(yàn)證脅迫是否影響生長(zhǎng)素輸出蛋白（PIN1）聚集,，研究人員給擬南芥施加異惡草胺（isoxaben）,，抑制其細(xì)胞壁纖維素合成。
結(jié)果證實(shí),，機(jī)械應(yīng)力影響PIN1的導(dǎo)向,。通過(guò)數(shù)學(xué)建模，研究人員發(fā)現(xiàn)一個(gè)與機(jī)械信號(hào)相互作用的生長(zhǎng)素運(yùn)輸系統(tǒng),，這個(gè)系統(tǒng)與活體樣本中的發(fā)現(xiàn)類似,，它可以驅(qū)動(dòng)擬南芥器官的快速生長(zhǎng)。因此在植物正常生長(zhǎng)發(fā)育和損傷修復(fù)的過(guò)程中,，機(jī)械信號(hào)的其他潛在功能值得進(jìn)一步探究,。（生物谷Bioon.com）
生物谷推薦英文摘要：
PLoS Biol 8(10): e1000516. doi:10.1371/journal.pbio.1000516
Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport
Marcus G. Heisler1#¤, Olivier Hamant2#, Pawel Krupinski3#, Magalie Uyttewaal2, Carolyn Ohno1¤, Henrik J?nsson3#*, Jan Traas2*, Elliot M. Meyerowitz1*
1 Division of Biology, California Institute of Technology, Pasadena, California, United States of America, 2 INRA, CNRS, ENS, Université de Lyon, Lyon Cedex, France, 3 Computational Biology and Biological Physics Group, Department of Theoretical Physics, Lund University, Lund, Sweden
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells. In particular, normal patterns of organogenesis in plants require coordination between growth direction and growth magnitude. How this is achieved remains unclear. Here we show that in Arabidopsis thaliana, auxin patterning and cellular growth are linked through a correlated pattern of auxin efflux carrier localization and cortical microtubule orientation. Our experiments reveal that both PIN1 localization and microtubule array orientation are likely to respond to a shared upstream regulator that appears to be biomechanical in nature. Lastly, through mathematical modeling we show that such a biophysical coupling could mediate the feedback loop between auxin and its transport that underlies plant phyllotaxis.
