一項最新研究發(fā)現(xiàn),，某種特殊的基因變異可能與心臟驟停有關(guān),，這一發(fā)現(xiàn)將有助于預(yù)防和治療心臟驟停,。
來自美國,、加拿大,、芬蘭和荷蘭等國的研究人員參加了這項研究。為探討遺傳變異與心臟驟停之間的關(guān)系,，研究人員將4402名心臟驟?；颊叩幕蚺c3萬名正常人的基因進行比對。研究發(fā)現(xiàn),，BAZ2B基因與心臟驟停有關(guān),，當(dāng)該基因發(fā)生變異時，心臟驟停的幾率會高于正常人兩倍,，而且往往會在沒有任何預(yù)兆的情況下發(fā)生,，所導(dǎo)致的死亡率高達95%。
研究人員表示,，他們正開始揭示心臟驟停的秘密及其預(yù)防方法,。如果等到患者心臟驟停時再治療，那就太遲了,。這就是事先搞清楚具有什么樣基因的人會得此病的重要性,。
心臟驟停是指心臟射血功能突然終止，大動脈搏動與心音消失,，重要器官如大腦嚴(yán)重缺血,、缺氧，導(dǎo)致生命終止,。（生物谷Bioon.com）
生物谷推薦原文出處：
PLoS Genetic doi:10.1371/journal.pgen.1002158
Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals
Dan E. Arking, etc
Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000–300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify the BAZ2B locus as associated with SCD (P = 1.8×10?10). The risk allele, while ancestral, has a frequency of ~1.4%, suggesting strong negative selection and increases risk for SCD by 1.92–fold per allele (95% CI 1.57–2.34). We also tested the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals). Consistent with epidemiological studies showing increased risk of SCD with prolonged QRS/QT intervals, the interval-prolonging alleles are in aggregate associated with increased risk for SCD (P = 0.006).
