2012年12月3日 訊 /生物谷BIOON/ --近日,，來(lái)自一項(xiàng)國(guó)際研究小組的研究人員通過(guò)研究揭示了,，四個(gè)和低出生體重相關(guān)的基因區(qū)域，其中三個(gè)基因區(qū)域影響個(gè)體成年后的代謝,，而且可以長(zhǎng)期影響機(jī)體情況,，比如成年后體重、患II型糖尿病風(fēng)險(xiǎn)以及成年血壓等,，相關(guān)研究成果刊登在國(guó)際雜志Nature Genetics上,。
來(lái)自埃克塞特大學(xué)醫(yī)學(xué)院等處的研究者通過(guò)對(duì)歐洲、亞洲,、非洲等地將近70，000名個(gè)體進(jìn)行綜合數(shù)據(jù)分析,，肯定了前期發(fā)現(xiàn)的3個(gè)遺傳區(qū)域和低出生體重風(fēng)險(xiǎn)增加相關(guān),，這項(xiàng)最新研究中，研究者發(fā)現(xiàn)了另外一些遺傳區(qū)域,，其和低出生體重也相關(guān),，為HMGA2,， LCORL,， ADRB1及染色體5號(hào)部位,。
以前鑒別出的兩個(gè)基因區(qū)域和II型糖尿病風(fēng)險(xiǎn)直接相關(guān),，第三個(gè)遺傳區(qū)域,，ADRB1和成年后血壓相關(guān),，這也是科學(xué)家第一次發(fā)現(xiàn)出生體重和成年后血壓有直接的關(guān)系,。
研究者Freathy說(shuō)道,，這些研究發(fā)現(xiàn)為我們研究控制嬰兒在母體中成長(zhǎng)的分子機(jī)制提供了重要的研究線索,，這或許可以幫助我們理解在婦女懷孕期間控制嬰兒生長(zhǎng)的一些情況,。
這項(xiàng)最新研究闡述了，早期發(fā)育的活性基因?qū)τ趥€(gè)體在幼年期以及成年期的健康效應(yīng),。研究者表示,，我們或許可以通過(guò)認(rèn)為地嬰兒出生前干預(yù)措施來(lái)改善嬰兒的出生體重，以改善其出生后的生長(zhǎng)和健康狀況,。相關(guān)研究由國(guó)立衛(wèi)生研究院等機(jī)構(gòu)提供資助,。（生物谷Bioon.com）
doi:10.1038/ng.2477
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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Momoko Horikoshi1, 2, 118 Hanieh Yaghootkar3, 118 Dennis O Mook-Kanamori4, 5, 6, 7, 118 Ulla Sovio8, 9 H Rob Taal4, 5, 6 Branwen J Hennig10, 11 Jonathan P Bradfield12 Beate St Pourcain13 David M Evans13 Pimphen Charoen8, 14 Marika Kaakinen15, 16 Diana L Cousminer17 Terho Lehtimäki18, 19 Eskil Kreiner-Møller20, 21 Nicole M Warrington22 Mariona Bustamante23, 24, 25, 26 Bjarke Feenstra27 Diane J Berry28 Elisabeth Thiering29 et al.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
