生物谷報(bào)道：今天剛剛出版的Science上刊登了2篇重要的文章,，美國(guó)科學(xué)工作者研究大腦是如何感知道疼痛的。采用了fMRI等手段研究了大腦感知疼痛的腦區(qū)分布,，作者采用安慰劑作為實(shí)驗(yàn)，實(shí)驗(yàn)設(shè)計(jì)和構(gòu)思巧妙,，有很強(qiáng)的說(shuō)服力這是疼痛機(jī)理研究的最新進(jìn)展,。
The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain.
Original articles
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Tania Singer, Ben Seymour, John O'Doherty, Holger Kaube, Raymond J. Dolan, and Chris D. Frith
Science 2004 303: 1157-1162. (in Research Articles) [Full Text] [PDF Version]
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Tor D. Wager, James K. Rilling, Edward E. Smith, Alex Sokolik, Kenneth L. Casey, Richard J. Davidson, Stephen M. Kosslyn, Robert M. Rose, and Jonathan D. Cohen
Science 2004 303: 1162-1167. (in Research Articles) [Full Text] [PDF Version]
Comment:
Imaging Studies Show How Brain Thinks About Pain.Science Volume 303, Number 5661, Issue of 20 Feb 2004, p. 1121 [Full Text] [PDF Version]
