生物谷報道：本篇文章發(fā)表在本期的Nature上,，這篇文章有助于人類對嗎啡成癮,，疼痛機理等認識,。非常值得一讀,。
Analgesia: Morphine-pathway block in top1 poppies
This opium poppy mutant provides chemical precursors for non-addictive analgesics.
The opium poppy is a source of the pharmaceuticals codeine, morphine and their derived analgesics. Here we describe the initial characterization of the poppy mutant known as top1 (for 'thebaine oripavine poppy 1'), which accumulates the morphine and codeine precursors thebaine and oripavine and does not complete their biosynthesis into morphine and codeine. The original discovery of top1 stimulated a re-engineering of the opioid industry in the island state of Tasmania, which grows over 40% of the world's licit opiates, in order to produce thebaine and oripavine efficiently from morphine-free poppy crops to provide precursors for highly effective analgesics and for treatment of opioid addiction.
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