生物谷報(bào)道：今天（1月14日）剛剛出版的Cell正式刊出中國科學(xué)院神經(jīng)科學(xué)研究所的文章,，早在兩個(gè)月前,，生物谷首次公開報(bào)道,，Cell正式接收中國大陸近二十五年來第一篇原創(chuàng)性Cell文章,，是中國生命科學(xué)領(lǐng)域的重大的突破,，詳細(xì)見：中科院神經(jīng)所蔣輝博士的論文已被Cell接收,，生物谷報(bào)道后,，在國內(nèi)引起了極大的反響，被全國各大網(wǎng)站,，BBS轉(zhuǎn)載,，同時(shí)許多研究工作者發(fā)表了精彩的評(píng)論，如管中窺豹——從蔣輝的信看神經(jīng)所氛圍,，為促進(jìn)國內(nèi)生命科學(xué)的發(fā)展起到積極的推動(dòng)作用,。
蔣輝博士在這篇報(bào)道中發(fā)現(xiàn)：GSK蛋白質(zhì)的活性對(duì)確定神經(jīng)細(xì)胞極性起關(guān)鍵作用，開拓了治療神經(jīng)損傷的新途徑,。
這篇具有開創(chuàng)性意義的文章主要來自于中科院上海生命科學(xué)研究院神經(jīng)科學(xué)研究所,，也是神經(jīng)所近數(shù)年來發(fā)表的一系列重大文章之一，附后（文章均可下載）,。
腦神經(jīng)復(fù)雜的信息傳導(dǎo)有賴神經(jīng)細(xì)胞的特殊結(jié)構(gòu),，神經(jīng)細(xì)胞通常有兩種結(jié)構(gòu) 接收訊號(hào)的樹突、發(fā)送訊號(hào)的軸突,。他們的研究揭示了神經(jīng)細(xì)胞的這兩個(gè)基本極性是如何形成的,，GSK蛋白激酶在發(fā)育過程中的分布有極性，在軸突中的活性比樹突中要低,。如果其活性太高,，神經(jīng)細(xì)胞會(huì)沒有軸突，太低則會(huì)把樹突變成軸突,。它的活性由上游分子來調(diào)控,，多個(gè)分子形成通路，控制著神經(jīng)細(xì)胞的極性,。還發(fā)現(xiàn),，確定神經(jīng)細(xì)胞極性的GSK還維持著極性。如果用藥物改變GSK活性,，就可以把樹突變成軸突,。這表明，可以通過藥物來增加軸突數(shù)量,，這可能成為神經(jīng)元損傷修復(fù)和退行性神經(jīng)系統(tǒng)疾病治療的新突破口,。
Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information flow. Here we report a differential distribution of GSK-3 activity in the axon versus the dendrites. A constitutively active GSK-3 mutant inhibited axon formation, whereas multiple axons formed from a single neuron when GSK-3 activity was reduced by pharmacological inhibitors, a peptide inhibitor, or siRNAs. An active mechanism for maintaining neuronal polarity was revealed by the conversion of preexisting dendrites into axons upon GSK-3 inhibition. Biochemical and functional data show that the Akt kinase and the PTEN phosphatase are upstream of GSK-3 in determining neuronal polarity. Our results demonstrate that there are active mechanisms for maintaining as well as establishing neuronal polarity, indicate that GSK-3 relays signaling from Akt and PTEN to play critical roles in neuronal polarity, and suggest that application of GSK-3 inhibitors can be a novel approach to promote generation of new axons after neural injuries.
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相關(guān)報(bào)道：
管中窺豹——從蔣輝的信看神經(jīng)所氛圍
中科院神經(jīng)所蔣輝博士的論文已被Cell接收
饒毅博士簡(jiǎn)介
蒲慕明所長(zhǎng)在神經(jīng)所2003年所年會(huì)上的講話
蒲慕明教授對(duì)神經(jīng)所的新年祝詞
蒲慕明博士簡(jiǎn)介 href="http://www.bioon.com/biology/talent/chinese/200411/83869.html" target=_blank>蒲慕明博士簡(jiǎn)介
附1：
神經(jīng)所近三年內(nèi)已發(fā)表的重要文章[PDF文件全部可以下載]
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Bao, L., Jin, S., Zhang, C., Wang, L., Xu, Z., Zhang, F., Wang, L., Ning, F., Cai, H., Guan, J., Xiao, H., Xu, Z., He, C., Hokfelt, T., Zhou, Z., and Zhang, X. (2003) Activation of delta-Opioid Receptors on Dorsal Root Ganglion Neurons Induces Receptor Insertion and Neuropeptide Secretion. Neuron 37, 121-133. [Abstract] [ PDF]
Yao, H., and Li, C. (2002) Clustered Organization of Neurons with Similar Extra-Receptive Field Properties in the Primary Visual Cortex. Neuron 35, 547-553. [Abstract][PDF]
Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X., Wu, C., Poo, M., and Duan, S. (2002) Nerve growth cone guidance mediated by G protein-coupled receptors. Nat. Neurosci. 5, 843-848. [Abstract][PDF]
Zhang, C., and Zhou, Z. (2002) Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat. Neurosci. 5, 425-430. [Abstract][PDF]
Xiao, H., Huang, Q., Zhang, F., Bao, L., Lu, Y., Guo, C., Yang, L., Huang, W., Fu, G., Xu, S., Cheng, X., Yan, Q., Zhu, Z., Zhang, X., Chen, Z., Han, Z., and Zhang, X. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.Proc. Natl. Acad. Sci. USA 99, 8360-8365. [Abstract][PDF]
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