生物谷援引華文生技網(wǎng)報道：近年來的診斷發(fā)現(xiàn)，兒童自閉癥(Autism)增加的原因,，可能與環(huán)境毒物有關(guān),，但是，美國密蘇里大學(xué)哥倫比亞分校(University of Missouri-Columbia)的科學(xué)家卻表示,，為保存Rh免疫球蛋白(Rh immune globulin，簡稱RhIg)而使用的含汞抗菌劑,，并不會提高孩童自閉癥的風(fēng)險,。此研究由Judith Miles教授主導(dǎo)調(diào)查，發(fā)表于American Journal of Medical Genetics PartA的在線期刊,，網(wǎng)址如下：http://www.interscience.wiley.com/ajmg,。
雖然有些專家們認(rèn)為自閉癥的主因可能為基因問題所導(dǎo)致，并已有大量的研究指出這些含有汞抗菌劑的疫苗與自閉癥無關(guān),，但仍有許多人繼續(xù)在這個含有50% 乙基汞的抗菌劑上爭論,，而美國FDA、CDC以及AAP也建議將這些含汞的抗菌劑從兒童疫苗中移除,，而此建議也于2002年達(dá)成,。雖然美國國內(nèi)已經(jīng)不在兒童疫苗中含有汞成份的抗菌劑，但目前仍有許多國家仍使用含汞抗菌劑的疫苗,。
此研究調(diào)查的對象包括214位母親及230個被診斷有自閉癥的孩童,，觀察他們的醫(yī)療記錄，結(jié)果顯示：這些自閉癥的孩童中,，他們的母親為Rh陰性的情況并不顯著,，而這些孩童在出生前使用含汞RhIg的比例也不特別高。這項研究的調(diào)查數(shù)據(jù)顯示含汞抗菌劑與兒童自閉癥并無直接關(guān)聯(lián)性,。
（編譯/陳瑞娟） (資料來源 : Bio.com)
英文原文鏈接：
原始出處：
Research Article
American Journal of Medical Genetics Part A,，Published Online: 16 May 2007
Lack of association between Rh status, Rh immune globulin in pregnancy and autism
Judith H. Miles *, T. Nicole Takahashi
Thompson Center for Autism and Neurodevelopmental Disorders, and Department of Child Health, University of Missouri Hospitals and Clinics, Columbia, Missouri
email: Judith H. Miles ([email protected])
*Correspondence to Judith H. Miles, Department of Child Health, Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri Hospitals and Clinics, #1 Hospital Drive, Columbia, MO 65212.
How to cite this article: Miles JH, Takahashi TN. 2007. Lack of association between Rh status, Rh immune globulin in pregnancy and autism. Am J Med Genet Part A.
Funded by:
Johnson and Johnson Company
Leda J. Sears Trust
Keywords
autism ?Rh ?Rh immune globulin ?thimerosal ?RhoGam
Abstract
Though causes of autism are considered largely genetic, considerable concern remains that exposure to Rh immune globulin (RhIg), which until 2001 in the United States contained the preservative thimerosal, can cause autism. To determine whether mothers of children with autism are more likely to be Rh negative (Rh-) or to have received RhIg preserved with thimerosal, which is 49.6% ethyl mercury, we surveyed families of children with an autism spectrum disorder (ASD) ascertained through a University-based autism clinic considered free of ascertainment biases related to type of autism or severity. Between 2004 and 2006, 305 mothers of 321 children with an ASD agreed to participate in a telephone interview. Analysis of complete records including the blood group status and RhIg exposure of 214 families showed that Rh- status is no higher in mothers of children with autism than in the general population, exposure to antepartum RhIg, preserved with thimerosal is no higher for children with autism and pregnancies are no more likely to be Rh incompatible. This was also true for autism subgroups defined by behavioral phenotype, gender, IQ, regressive onset, head circumference, dysmorphology, birth status, essential, or complex phenotype. These findings support the consensus that exposure to ethylmercury in thimerosal is not the cause of the increased prevalence of autism. These data are important not only for parents in this country but also for the international health community where thimerosal continues to be used to preserve multi-dose vials which in turn makes vaccines affordable. © 2007 Wiley-Liss, Inc.
