生物谷報(bào)道：多巴胺是一種重要的神經(jīng)調(diào)質(zhì)，它參與許多簡單行為和復(fù)雜行為的調(diào)控,。多巴胺系統(tǒng)對(duì)性行為的調(diào)控在哺乳動(dòng)物中已得到廣泛研究,。最近中科院神經(jīng)所的研究人員發(fā)現(xiàn)升高多巴胺細(xì)胞中多巴胺水平可以誘發(fā)很強(qiáng)的雄性果蠅間的同性求偶行為。相關(guān)論文發(fā)表在新一期《神經(jīng)科學(xué)雜志》上,。
求偶行為對(duì)于動(dòng)物物種的繁衍和其對(duì)環(huán)境的適應(yīng)都是非常重要的,。果蠅的求偶行為是一個(gè)復(fù)雜的過程，它包括六個(gè)步驟：雄蠅轉(zhuǎn)向雌蠅,，拍打,，唱求偶歌，舔雌蠅尾端,，試圖交尾和交尾成功。雖然求偶行為通常發(fā)生在異性之間,，但某些基因的突變和異位表達(dá)可以誘發(fā)雄性果蠅間的求偶行為,。
二零零四年五月，郭愛克研究員帶領(lǐng)其研究組，以果蠅為模式動(dòng)物,，研究多巴胺水平在帕金森病的神經(jīng)基礎(chǔ)中扮演的角色時(shí),，十分偶然地發(fā)現(xiàn)升高多巴胺細(xì)胞中多巴胺水平可以誘發(fā)很強(qiáng)的雄性果蠅間的同性求偶行為。研究人員利用遺傳學(xué)和藥理學(xué)方法調(diào)控果蠅多巴胺細(xì)胞中多巴胺水平來研究多巴胺水平過高對(duì)果蠅雄性之間求偶行為的影響,，并發(fā)現(xiàn)高水平多巴胺可以大幅度提高雄性果蠅同性間求偶的傾向,，但并沒有顯著性地影響到對(duì)果蠅異性求偶行為、雄蠅自身的吸引性,、短期自發(fā)運(yùn)動(dòng)活性及普遍的嗅覺和味覺感知,。研究表明這種高多巴胺果蠅所表現(xiàn)的雄性同性求偶行為與其視覺和嗅覺系統(tǒng)對(duì)雄蠅的感知改變相關(guān)。他們的研究成果說明,，多巴胺神經(jīng)系統(tǒng)在調(diào)控果蠅雄雄求偶行為中起著重要作用,。雖然目前我們還不知道這樣的結(jié)果是否也適用于其它物種，多巴胺系統(tǒng)紊亂是怎樣影響果蠅求偶行為的也仍然是未知問題,，但是對(duì)果蠅雄雄求偶行為進(jìn)一步研究將有助于我們了解和闡釋果蠅性行為的精細(xì)調(diào)控機(jī)制,。科學(xué)家普遍認(rèn)為多巴胺,，五羥色胺和去甲腎上腺素等共同參于人的許多認(rèn)知和精神活動(dòng),。但是，研究人員表示不應(yīng)將在果蠅上的研究結(jié)果任意外延到其他動(dòng)物物種,。（生物谷www.bioon.com）
生物谷推薦原始出處：
Journal of Neuroscience,，28(21):5539-5546，Tong Liu,，Aike Guo
Increased Dopamine Level Enhances Male–Male Courtship in Drosophila
Tong Liu,1,2 Laurence Dartevelle,4 Chunyan Yuan,1 Hongping Wei,1,2 Ying Wang,1 Jean-François Ferveur,4 and Aike Guo1,3
1Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, 2Graduate School of Chinese Academy of Sciences, Beijing 100039, China, 3State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, and 4Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5548, Universite de Bourgogne, Dijon 21000, France
Correspondence should be addressed to either of the following: Aike Guo, Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Email: [email protected] ; or Jean-François Ferveur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5548, Universite de Bourgogne, Dijon 21000, France, E-mail: Email: [email protected]
Sexual behavior between males is observed in many species, but the biological factors involved are poorly known. In mammals, manipulation of dopamine has revealed the role of this neuromodulator on male sexual behavior. We used genetic and pharmacological approaches to manipulate the dopamine level in dopaminergic cells in Drosophila and investigated the consequence of this manipulation on male–male courtship behavior. Males with increased dopamine level showed enhanced propensity to court other males but did not change their courtship toward virgin females, general olfactory response, general gustatory response, or locomotor activity. Our results indicate that the high intensity of male–male interaction shown by these manipulated males was related to their altered sensory perception of other males.
