生物谷報(bào)道：北京生命科學(xué)研究所研究人員22日在《神經(jīng)元》雜志發(fā)表了一篇關(guān)于嗅覺(jué)機(jī)制的文章,。該文章報(bào)道了小鼠嗅球兩側(cè)對(duì)稱(chēng)的嗅覺(jué)圖譜通過(guò)大腦中一個(gè)特化的嗅覺(jué)區(qū)域精確地連接起來(lái)，以及此連接在嗅覺(jué)信息傳遞中有重要作用,。
感覺(jué)系統(tǒng)用在大腦兩側(cè)對(duì)稱(chēng)排列的精確感覺(jué)圖譜來(lái)代表如圖像、氣味等生理刺激,。但是,，大腦兩側(cè)對(duì)稱(chēng)的感覺(jué)圖譜是怎么連接的仍然不清楚。研究數(shù)據(jù)表明,，一個(gè)很少研究的嗅覺(jué)皮層核團(tuán)——前外側(cè)嗅核(anterior olfactory nucleus pars externa),，精確地把位于嗅球兩側(cè)對(duì)稱(chēng)的嗅覺(jué)圖譜連接起來(lái)。電生理和行為分析進(jìn)一步表明前外側(cè)嗅核對(duì)兩側(cè)嗅球的氣味信息交換包括嗅覺(jué)記憶有必要的作用,。
通過(guò)對(duì)割裂腦病人（兩側(cè)大腦被分開(kāi)的病人）的研究,，羅杰·斯佩里(Roger W. Sperry)等發(fā)現(xiàn)兩側(cè)大腦的連接對(duì)于認(rèn)知與行為起著重要作用，并于1981年獲得諾貝爾獎(jiǎng),，但大腦兩側(cè)相互作用的機(jī)理至今仍然是一個(gè)謎團(tuán),。本文發(fā)現(xiàn)兩側(cè)嗅球通過(guò)前外側(cè)嗅核的精確連接，為進(jìn)一步揭開(kāi)兩側(cè)大腦相互作用的機(jī)理提供了一個(gè)可以基因操作的模型,。該期《神經(jīng)元》雜志專(zhuān)門(mén)為該文發(fā)表了一篇題為“Interhemispheric Olfactory Circuit and the Memory Beyond”的評(píng)述文章,。（生物谷www.bioon.com）
生物谷推薦原始出處：
Neuron，Vol 58, 613-624,，Zhiqiang Yan,，Minmin Luo
Precise Circuitry Links Bilaterally Symmetric Olfactory Maps
Zhiqiang Yan,1,2 Jie Tan,1,2 Chang Qin,2 Yao Lu,2 Cheng Ding,2 and Minmin Luo2,
1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
2 National Institute of Biological Sciences, Beijing, 102206, China
Corresponding author
Minmin Luo
[email protected]
Olfactory sensory neurons expressing a common receptor gene converge onto one or a few glomeruli with stereotyped positions within the mouse main olfactory bulb (MOB), producing a map of ∼1800 olfactory columns representing ∼1000 odorant receptors. Here, we report that this precise olfactory map is maintained over several synapses that ultimately cross MOB hemispheres to link bilateral isofunctional olfactory columns. Focal injection of tracer into genetically identified glomeruli revealed an exquisite topography that involves a bilateral connection via the anterior olfactory nucleus pars externa (AONpE) that links isofunctional olfactory columns in the contralateral MOB. Physiological and behavioral assays revealed an important role for the AONpE in bilateral exchange of odorant-specific information. These results indicate that the interbulbar link through the AONpE integrates bilateral olfactory sensory maps and exchanges olfactory information, positioning it as a unique model system for studying interhemispheric connections.
