生物谷報道：美國科學家發(fā)現(xiàn)，人在饑餓時胃黏膜會分泌一種饑餓激素,，可以減輕心理壓力,，預防抑郁與焦慮的情緒。這一研究成果發(fā)表在《自然—神經(jīng)學》（Nature Neuroscience）上,。
美國得州大學西南醫(yī)學中心的科研人員完成了這一研究,，該中心內科學和精神病學教授杰弗里·齊格曼博士表示，使人產(chǎn)生饑餓感的主要原因是胃中的激素,。
在釋放這種激素時,，人們會對食物產(chǎn)生興趣，同時,，抑郁或焦慮情緒也會減輕,，抵抗壓力的能力會明顯增強。“盡管饑餓激素可能讓人們吃得多,，但也會讓你有一份好心情,。”齊格曼說，一方面對食物的興趣分散了我們對壓力來源的注意,，另一方面,，這種激素會向大腦發(fā)出信號，讓身體進行自我調節(jié),，“想到美味的食物,，心情應該不會太差吧，熱愛美食的人一般都比較樂觀,。”
過去研究者曾通過抑制饑餓激素的分泌,，幫助減肥。目前,，他們正在研究利用饑餓激素,，幫助厭食者和抑郁癥患者,，通過增加饑餓激素，使這些人發(fā)生積極變化,。（生物谷www.bioon.com）
生物谷推薦原始出處：
Nature Neuroscience,，doi:10.1038/nn.2139，Michael Lutter,，Jeffrey M Zigman
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Michael Lutter1, Ichiro Sakata2, Sherri Osborne-Lawrence2, Sherry A Rovinsky2, Jason G Anderson2, Saendy Jung1, Shari Birnbaum1, Masashi Yanagisawa3, Joel K Elmquist1,2,4, Eric J Nestler1 & Jeffrey M Zigman2
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
Department of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism), The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
