多巴胺是大腦中的一種神經(jīng)遞質(zhì)。科學(xué)家們發(fā)現(xiàn)，個體對負(fù)面情緒線索的不同反應(yīng)主要基于大腦中多巴胺的儲存數(shù)量，新成果發(fā)表在日前在線出版的《自然—神經(jīng)科學(xué)》期刊上,，將有助于解釋為什么不同的人以不同的方式應(yīng)對壓力或情感事件。
大腦扁桃體是負(fù)責(zé)處理情感的區(qū)域,。Andreas Heinz和同事測量了扁桃體中的多巴胺儲存量,，觀察到多巴胺儲存量與情感處理方式間的關(guān)系。他們發(fā)現(xiàn),，當(dāng)注視令人不快的圖片時,，擁有高水平多巴胺儲存量的個體在其大腦的扁桃體和前扣帶皮層區(qū)域有更活躍的活動。而且,，與扁桃體和前扣帶皮層相關(guān)的功能與受試者的標(biāo)準(zhǔn)焦慮測試成績成反比關(guān)系,。
新工作有助于解釋多巴胺儲存量的不同為何導(dǎo)致個體氣質(zhì)的差異，特別是當(dāng)它們與人們壓力或情緒事件處理相關(guān)時,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Neuroscience,，doi:10.1038/nn.2222，Thorsten Kienast,，Andreas Heinz
Dopamine in amygdala gates limbic processing of aversive stimuli in humans
Thorsten Kienast1, Ahmad R Hariri2, Florian Schlagenhauf1, Jana Wrase1, Philipp Sterzer1, Hans Georg Buchholz3, Michael N Smolka4, Gerhard Gründer5, Paul Cumming6, Yoshitaka Kumakura7, Peter Bartenstein6, Raymond J Dolan8 & Andreas Heinz1
Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[18F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level–dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.
1 Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.
2 Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213, USA.
3 Department of Nuclear Medicine, Johannes Gutenberg University of Mainz, Langenbeck Strasse 1, 55131 Mainz, Germany.
4 Section of Systems Neuroscience, Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, Technische Universit?t Dresden, Würzburger Strasse 35, 01187 Dresden, Germany.
5 Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
6 Department of Nuclear Medicine, Ludwig Maximilian University, Campus Grohadern, Marchioninistrasse 15, 81377 Munich, Germany.
7 Department of Nuclear Medicine and Research Center for Advanced Science and Technology, Tokyo University, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.
8 Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK.
