日本專家發(fā)現(xiàn),，用藍(lán)光照射大白鼠受損的脊髓神經(jīng)細(xì)胞,，可令促進(jìn)細(xì)胞成長的蛋白質(zhì)增加,，進(jìn)而加速受損部分恢復(fù),。
據(jù)日本共同社12日?qǐng)?bào)道，名古屋市立大學(xué)教授岡嶋研二和副教授原田直明把10只脊髓受傷的大白鼠分成兩組,，其中一組每天接受波長470納米的藍(lán)光照射20分鐘,，堅(jiān)持3周，另一組不接受任何治療,。
3周后,，接受藍(lán)光照射的一組實(shí)驗(yàn)鼠都恢復(fù)到能夠行走的水平，而另外一組仍處于麻痹狀態(tài),。
研究人員觀察到,，接受藍(lán)光照射的實(shí)驗(yàn)鼠的神經(jīng)細(xì)胞變得更大，神經(jīng)細(xì)胞內(nèi)促進(jìn)細(xì)胞成長的蛋白質(zhì)胰島素樣生長因子1（IGF－1）增加到原先的約1．7倍,。
研究人員認(rèn)為,，胰島素樣生長因子1在藍(lán)光刺激下增加,，有助于抑制細(xì)胞死亡,，促進(jìn)干細(xì)胞的分化和新生細(xì)胞的成長。
這項(xiàng)成果有望應(yīng)用于治療運(yùn)動(dòng)麻痹及癡呆癥等疾病,。（生物谷Bioon.com）
生物谷推薦原始出處：
EFFECT OF BLUE LIGHT THERAPY ON COGNITIVE FUNCTION AND SERUM INSULIN-LIKE GROWTH FACTOR I (IGF-I) LEVEL IN ALZHEIMER'S DISEASE
R. Toriya1, H. Tanaka1, B. Yamagata1, K. Okajima2, H. Yamamoto1, H. Tomioka1, M. Mimura1
1Showa University, Neuropsychiatry, Tokyo, Japan, 2Nagoya City University, Nagoya, Japan
Aims: It has been reported that white color light therapy is partially effective for improving circadian rhythm and behavioural problems in Alzheimer's disease (AD). In the present study, we investigated whether blue light therapy ameliorates cognitive functions in AD. Previous experiments demonstrated that blue light improves new learning in mice by stimulating sensory nerves and increasing the serum level of insulin-like growth factor-I (IGF-I). We previously documented that serum IGF-I level was lower in AD than healthy controls and that IGF-I level would be a predictor for responsiveness of donepezil. Accordingly, we hypothesized that blue light therapy would increase serum IGF-I level in AD patients, thereby enhancing their cognitive functions.
Methods: Six inpatients with AD participated in the study who matched the diagnostic criteria of NINCDS-ADRDA. The patients received on their back 1,000 lux blue light with 460 - 470 nm for 20 minutes every evening for two weeks. Serum IGF-I and IGF-BP3 levels, and cognitive functions as measured by Mini-Mental State Examination (MMSE) and AD Assessment Scale (ADAS-JCog) scores were explored twice; before and after the blue light therapy. The study was approved by the Ethics Committee at Showa University School of Medicine.
Results: Two weeks' blue light therapy mildly improved cognitive function as indexed by MMSE and ADAS-JCog. In addition, serum IGF-I level of the participants increased following blue light therapy.
Conclusions: The results suggest that blue light therapy increases serum IGF-I level and improves cognitive functions in AD.
