法國(guó)國(guó)家科研中心的研究人員日前通過(guò)試驗(yàn)發(fā)現(xiàn),，注射催產(chǎn)素能夠顯著緩解孤獨(dú)癥患者的癥狀，這一發(fā)現(xiàn)將為醫(yī)學(xué)界開(kāi)發(fā)治療孤獨(dú)癥的藥物提供新思路,。
法國(guó)研究人員在最新一期的美國(guó)《國(guó)家科學(xué)院學(xué)報(bào)》（PNAS）上報(bào)告說(shuō)，催產(chǎn)素是腦下垂體后葉分泌的一種激素,，它不但能促進(jìn)臨產(chǎn)孕婦的子宮收縮,，幫助其分娩，還在人的社會(huì)行為和情感表達(dá)中起著關(guān)鍵作用,。此前曾有研究發(fā)現(xiàn),，孤獨(dú)癥患者血液中催產(chǎn)素的含量嚴(yán)重不足。
為了進(jìn)一步證實(shí)催產(chǎn)素對(duì)人的社交行為的影響,，由安杰拉·西里古領(lǐng)導(dǎo)的科研小組給13名孤獨(dú)癥患者注射了催產(chǎn)素,，這些患者具有正常的智力和語(yǔ)言水平，但無(wú)法主動(dòng)參與社交活動(dòng),，比如在與其他人的談話中,，他們會(huì)盡量避免與對(duì)話者進(jìn)行眼神的交流,。科研人員隨后通過(guò)傳球游戲等試驗(yàn)發(fā)現(xiàn),，注射了催產(chǎn)素的孤獨(dú)癥患者社交恐懼感有所減輕,，更喜歡與他人玩耍，表現(xiàn)得更自信,。
科研人員下一步將對(duì)催產(chǎn)素的長(zhǎng)效機(jī)制及其對(duì)孤獨(dú)癥早期癥狀改善的有效性進(jìn)行研究,。（生物谷Bioon.com）
生物谷推薦原始出處：
PNAS February 16, 2010, doi:10.1073/pnas.0910249107
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders
Elissar Andaria, Jean-René Duhamela, Tiziana Zallab, Evelyn Herbrechtb, Marion Leboyerb, and Angela Sirigua
Social adaptation requires specific cognitive and emotional competences. Individuals with high-functioning autism or with Asperger syndrome cannot understand or engage in social situations despite preserved intellectual abilities. Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism. We investigated the behavioral effects of oxytocin in 13 subjects with autism. In a simulated ball game where participants interacted with fictitious partners, we found that after oxytocin inhalation, patients exhibited stronger interactions with the most socially cooperative partner and reported enhanced feelings of trust and preference. Also, during free viewing of pictures of faces, oxytocin selectively increased patients’ gazing time on the socially informative region of the face, namely the eyes. Thus, under oxytocin, patients respond more strongly to others and exhibit more appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its action on a core dimension of autism.
