11月14日在線發(fā)表于《神經(jīng)病學(xué)年鑒》（Ann Neurol）上的美國一項(xiàng)研究"Solvent exposures and parkinson disease risk in twins"顯示,，暴露于特定溶劑可能增加帕金森?。≒D）患病風(fēng)險(xiǎn)。
研究納入99對PD狀況不一致的雙胞胎,，采用問卷評(píng)估終生職業(yè)和愛好,。結(jié)果為，既往暴露于三氯乙烯（TCE）與PD風(fēng)險(xiǎn)顯著升高相關(guān)[比值比（OR）為6.1,；P=0.034],，暴露于四氯乙烯（PERC）和四氯化碳（CCl4）傾向于具顯著相關(guān)性（OR分別為10.5和2.3；P分別為0.053和0.088）,。暴露持續(xù)時(shí)間和累積終生暴露的相關(guān)估計(jì)結(jié)果與之相似,。（生物谷Bioon.com）
doi:10.1002/ana.22629
PMC:
PMID:
Solvent exposures and parkinson disease risk in twins
Samuel M. Goldman MD, MPH1,*, Patricia J. Quinlan MPH, CIH2, G. Webster Ross MD3, Connie Marras MD, PhD4, Cheryl Meng MS1, Grace S. Bhudhikanok PhD1, Kathleen Comyns MPH1, Monica Korell MPH1, et al.
Objective:Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.
Methods:Ninety-nine twin pairs discordant for PD ascertained from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job task–specific questionnaires. Exposures to 6 specific solvents selected a priori were estimated by expert raters unaware of case status.
Results:Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (odds ratio [OR], 6.1; 95% confidence interval [CI] 1.2–33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl4) tended toward significance (respectively: OR, 10.5; 95% CI, 0.97–113; p = 0.053; OR, 2.3; 95% CI, 0.9–6.1; p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.
Interpretation:Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl4 are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.
