目前,，一項(xiàng)發(fā)表在Psychiatry Res雜志上的研究"An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample"指出,，與出生體重正常的新生兒相比，出生體重較高（HBW）的新生兒發(fā)展為精神分裂癥的風(fēng)險(xiǎn)增加2倍,。
本項(xiàng)研究發(fā)現(xiàn)與低體重與精神分裂癥相關(guān)這一結(jié)果相矛盾,，但與先前的4項(xiàng)研究結(jié)果相一致。
Asko Wegelius（National Institute for Health and Welfare, Helsinki, Finland）和他的同事們說道：“本研究發(fā)現(xiàn)與先前的研究結(jié)果相一致,，即HBW是發(fā)展為精神分裂癥的一種可能的危險(xiǎn)因素,，這提示我們可能需要對與精神分裂癥相關(guān)的低體重兒和高體重兒進(jìn)行評估。”
本研究納入來自315個(gè)Finnish家庭的1,051例兒童,， 這些家庭中至少有一例兒童被診斷為精神分裂癥,，對受試者的出生體重?cái)?shù)據(jù)進(jìn)行評估,。同時(shí)，通過從藥物報(bào)銷登記處獲取相關(guān)信息和問診的方式,，對罹患II型糖尿病的母親和其子女罹患精神分裂癥風(fēng)險(xiǎn)之間的相關(guān)性進(jìn)行探討,。
生存曲線分析顯示，出生體重2500-2999g和3000-4000g的風(fēng)險(xiǎn)軌跡相似,。出生體重>4000g與發(fā)展為精神分裂癥相關(guān),。出生體重<2500g的風(fēng)險(xiǎn)軌跡介于精神分裂癥和主要精神障礙組的高體重和中間體重風(fēng)險(xiǎn)軌跡之間。
對出生體重,、性別,、產(chǎn)婦和父親的精神障礙史進(jìn)行校正后，HBW新生兒發(fā)展為精神分裂癥的風(fēng)險(xiǎn)增加1.68倍,。HBW與主要的精神障礙之間無相關(guān)性,。此外低體重（LBW）與主要的精神障礙和精神分裂癥之間無相關(guān)性。
罹患糖尿病的母親,，其子女的出生體重與無糖尿病母親的子女相似,。罹患糖尿病的母親與高體重（HBW）新生兒之間無相關(guān)性。然而,，母親罹患糖尿病與其子女發(fā)展為精神分裂癥和主要精神障礙高度相關(guān),，其風(fēng)險(xiǎn)率比值（HRR）分別為1.66和1.55。
本項(xiàng)研究的作者們指出,，HBW或母親罹患糖尿病增加精神分裂癥風(fēng)險(xiǎn),，而非增加主要精神障礙易感性風(fēng)險(xiǎn)，這提示精神分裂癥和非精神分裂性-精神障礙之間的潛在病因?qū)W機(jī)制具有部分獨(dú)立性,。（生物谷Bioon.com）
doi:10.1016/j.psychres.2011.05.035
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An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample
Asko Wegelius,Annamari Tuulio-Henriksson,Maiju Pankakoski,Jari Haukka,Ulriika Lehto,Tiina Paunio,Jouko L.nnqvist,Jaana Suvisaari
Longitudinal cohort studies have implicated an association between both low and high birth weight and schizophrenia. It has been suggested that schizophrenia associated genes could augment an individual's susceptibility to adverse prenatal and perinatal environmental events. We investigated the association between birth weight and schizophrenia in a large Finnish schizophrenia family study sample. We utilized the birth weight data of 1051 offspring from 315 Finnish families with at least one offspring with a diagnosis of schizophrenia. We used a multivariate COX frailty model to analyze the effect of birth weight on the risk of developing schizophrenia within the families. Using information from the Medication Reimbursement Register and patient interviews, we further investigated the association of maternal type 2 diabetes and schizophrenia risk among offspring. High birth weight (>4000g) was associated with a 1.68-fold increase in schizophrenia susceptibility. Maternal diabetes at the time of data collection, a proxy for gestational diabetes, was associated with a 1.66-fold increase in the risk of developing schizophrenia among offspring. Our results corroborate recent findings showing an association between high birth weight and schizophrenia. Our results also point to a potential birth-weight independent association between maternal type 2 diabetes and schizophrenia among offspring.
