根據(jù)Sanjay Tyagi博士和新澤西醫(yī)學和牙科大學的同事們的研究表明：蛋白前體對脊椎延伸中神經(jīng)信號的單一傳輸是必需的。
這項研究最近發(fā)表在PNAS雜志上,。
軸突尖端和神經(jīng)元的突觸信號傳輸過程中涉及的蛋白質(zhì)以前體形式（信使RNA或mRNA）傳輸,。新澤西醫(yī)學院醫(yī)學系、公共健康研究所Tyagi副教授解釋說：位于突觸的基因被翻譯[成蛋白質(zhì)]是必需,。Tyagi補充說：如果該部位需要一種蛋白質(zhì)的多個副本，它可以由一個單一的基因產(chǎn)生。
一些研究者認為這些mRNAs與其他mRNAs存在“拼車”現(xiàn)象,。但Tyagi和他的同事的研究表明這些mRNAs以單個文件形式傳輸，每個顆粒只表達一種mRNA,。盡管單程運輸多個mRNAs可能看起來更高效,，但這可能利于神經(jīng)元突觸的形成和神經(jīng)運作所需要的靈活性。
進一步了解這些mRNAs是如何被運送到神經(jīng)突觸可能有助于科學家解開記憶產(chǎn)生的奧秘,，記憶形成過程需要形成新的突觸和舊突觸的修改,。（生物谷：Bioon）
doi:10.1073/pnas.1111226109
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Neuronal mRNAs travel singly into dendrites.
M. Batish, P. van den Bogaard, F. R. Kramer, S. Tyagi.
RNA transport granules deliver translationally repressed mRNAs to synaptic sites in dendrites, where synaptic activity promotes their localized translation. Although the identity of many proteins that make up the neuronal granules is known, the stoichiometry of their core component, the mRNA, is poorly understood. By imaging nine different dendritically localized mRNA species with single-molecule sensitivity and subdiffraction-limit resolution in cultured hippocampal neurons, we show that two molecules of the same or different mRNA species do not assemble in common structures. Even mRNA species with a common dendritic localization element, the sequence that is believed to mediate the incorporation of these mRNAs into common complexes, do not colocalize. These results suggest that mRNA molecules traffic to the distal reaches of dendrites singly and independently of others, a model that permits a finer control of mRNA content within a synapse for synaptic plasticity.
