2012年9月17日 訊 /生物谷BIOON/ --近日,，國際期刊Social Cognitive and Affective Neuroscience發(fā)表的一項(xiàng)研究結(jié)果表明,，患厭食癥的女性和正常女性在評(píng)價(jià)自己時(shí)的大腦活動(dòng)有區(qū)別。
研究人員讓參與此項(xiàng)研究的女性評(píng)價(jià)自己和自己的朋友,，同時(shí)用功能性核磁共振成像（functional magnetic resonance imaging,，fMRI）記錄她們的大腦活動(dòng)。參與者的任務(wù)包括閱讀和三項(xiàng)評(píng)價(jià)：自我評(píng)價(jià),，評(píng)價(jià)自己的一個(gè)親密的女性朋友及朋友眼中的自己,。在評(píng)價(jià)自己時(shí)，患厭食癥的女性與正常女性大腦活動(dòng)不同,。Krawczyk博士說自我評(píng)價(jià)時(shí)的大腦活動(dòng)不同可能導(dǎo)致了厭食癥的發(fā)生和維持,，而厭食癥關(guān)系到的不僅僅是食物本身，也影響了患者對(duì)自己和對(duì)社會(huì)的認(rèn)識(shí),。
研究者通過fMRI觀察了大腦楔前葉的兩個(gè)區(qū)域--前扣帶回和左額葉腦中間,，進(jìn)一步證實(shí)，楔前葉與自我意識(shí)（self-consciousness）和反射自我意識(shí)(reflectiveself-awareness)有關(guān),。
此項(xiàng)研究有助于厭食癥的診斷,，在下一步的研究中，研究者希望知道改變這兩個(gè)大腦區(qū)域是否可以達(dá)到治療的目的,。
根據(jù)美國國家神經(jīng)性厭食和相關(guān)疾病協(xié)會(huì)（National Association of Anorexia Nervosa and Associated Disorders）的統(tǒng)計(jì),，美國有超過240萬人有飲食障礙，女性的患病率達(dá)4%,。神經(jīng)性厭食癥的死亡率高達(dá)10%,，治療方法是改變患者的飲食習(xí)慣，使得他們的飲食營養(yǎng)均衡,，但是僅僅改變飲食無法治愈疾病本身,。（生物谷Bioon.com）
編譯自Study shows brain function differences in women with anorexia
doi:10.1093/scan/nss093
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NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
Hiroyasu Yamamoto, Evan G. Williams, Laurent Mouchiroud, Carles Cantó, Weiwei Fan, Michael Downes, Christophe Héligon, Grant D. Barish, Béatrice Desvergne, Ronald M. Evans et al.
Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.
