2012年11月6日 訊 /生物谷BIOON/ --治療很多疾病的止痛藥物或許對(duì)病人來(lái)說(shuō)還有別的用途,，近日，刊登在國(guó)際雜志Journal of Neuroscience上的研究報(bào)告中,，來(lái)自弗里德里希-席勒大學(xué)等處的研究者揭示了局部麻醉可以明顯改善中風(fēng)病人的運(yùn)動(dòng)技能,。
研究者Thomas表示，許多中風(fēng)病人表現(xiàn)出慢性的手部損傷或者手臂的完全損傷,。在“約束誘導(dǎo)運(yùn)動(dòng)療法”（CIMT）中,，患者健康的手臂處于限制狀態(tài)，而其受中風(fēng)所影響的手臂處于緊密的訓(xùn)練中來(lái)恢復(fù)運(yùn)動(dòng)機(jī)能,。研究者表示其很高興進(jìn)行這項(xiàng)療法,，療法中，病人需要進(jìn)行堆積小玩具或者把小針插進(jìn)一個(gè)穿孔板等任務(wù)和訓(xùn)練,，每一位患者都可以從這種新型療法中受益,。
當(dāng)受影響手臂的敏感性隨著麻醉程度而降低的時(shí)候，病人運(yùn)動(dòng)療法的作用就會(huì)明顯增強(qiáng),，在研究中,，研究者對(duì)36位病人進(jìn)行了檢測(cè)，其中一半的病人使用局部麻醉膏涂于其前臂上,，于此同時(shí),，其余的病人僅僅接受安慰劑治療。隨后所有的病人都開(kāi)始進(jìn)行每日的運(yùn)動(dòng)療法,。
通過(guò)研究,，所有病人的運(yùn)動(dòng)表現(xiàn)都明顯地增強(qiáng)了，而且病人接受麻醉劑所得到的效用明顯優(yōu)于接受安慰劑,。
未來(lái)的研究中,，研究者試圖去揭示是否局部麻醉藥和運(yùn)動(dòng)性療法的結(jié)合可以改善長(zhǎng)期改善中風(fēng)病人的運(yùn)動(dòng)能力。如果研究成功,，無(wú)疑可以更有效的改善病人的生活質(zhì)量,。（生物谷Bioon.com）
編譯自：Therapy for Stroke Patients Improved: More Mobility Due to Deafferentation
doi:10.1523/JNEUROSCI.5912-11.2012
PMC:
PMID:
Effects of Temporary Functional Deafferentation on the Brain, Sensation, and Behavior of Stroke Patients
Elisabeth Sens1, Ulrike Teschner1,2, Winfried Meissner3, Christoph Preul2, Ralph Huonker2, Otto W. Witte2, Wolfgang H. R. Miltner1, and Thomas Weiss1
Following stroke, many patients suffer from chronic motor impairment and reduced somatosensation in the stroke-affected body parts. Recent experimental studies suggest that temporary functional deafferentation (TFD) of parts of the stroke-affected upper limb or of the less-affected contralateral limb might improve the sensorimotor capacity of the stroke-affected hand. The present study sought evidence of cortical reorganization and related sensory and motor improvements following pharmacologically induced TFD of the stroke-affected forearm. Examination was performed during 2 d of Constraint-Induced Movement Therapy. Thirty-six human patients were deafferented on the stroke-affected forearm by an anesthetic cream (containing lidocaine and prilocaine) on one of the 2 d, and a placebo cream was applied on the other. The order of TFD and placebo treatment was counterbalanced across patients. Somatosensory and motor performance were assessed using a Grating orienting task and a Shape-sorter-drum task, and with somatosensory-evoked magnetic fields. Evoked magnetic fields showed significant pre- to postevaluation magnitude increases in response to tactile stimulation of the thumb of the stroke-affected hand during TFD but not following placebo treatment. We also observed a rapid extension of the distance between cortical representations of the stroke-affected thumb and little finger following TFD but not following placebo treatment. Moreover, somatosensory and motor performance of the stroke-affected hand was significantly enhanced during TFD but not during placebo treatment. Thus, pharmacologically induced TFD of a stroke-affected forearm might improve the somatosensory and motor functions of the stroke-affected upper limb, accompanied by cortical plasticity.
