2012年12月3日 訊 /生物谷BIOON/ --近日,，刊登在國際雜志the Journals of Gerontology Series A：Biological Sciences and Medical Sciences上的兩項(xiàng)研究成果揭示了,，維生素D或許是改善婦女認(rèn)知能力的重要成分。

飲食中較高水平維生素D的攝入和低風(fēng)險(xiǎn)的阿爾茲海默癥風(fēng)險(xiǎn)直接相關(guān),，來自明尼阿波利斯（Minneapolis）退伍軍人醫(yī)療中心的研究者指出,，在老年婦女中，低水平的維生素D和高風(fēng)險(xiǎn)的認(rèn)知損傷,、認(rèn)知功能下降直接相關(guān),。

研究者Slinin對6257名社區(qū)長期居住的老年婦女進(jìn)行研究揭示了，低水平的維生素D（每毫升血液中少于10毫微克）和高風(fēng)險(xiǎn)的認(rèn)知功能損傷直接相關(guān),，每毫升血液中維生素D少于20毫微克的老年婦女,，其患認(rèn)知功能下降的風(fēng)險(xiǎn)明顯增加。

另外研究者Annweieler度498名社區(qū)常住婦女進(jìn)行了研究,，發(fā)現(xiàn)患有阿爾茲海默癥的患者,，其攝入的維生素D水平較低，平均每周攝入50.3微克,，而患別的癡呆的患者其每周攝入63.6微克,，沒有任何癡呆的個(gè)體其每周維生素D的攝入為59.0微克。

這些研究成果揭示了,，無論是男性還是女性,，如果日常維生素D攝入不夠，那么其患運(yùn)動性限制疾病或者認(rèn)知?dú)埣驳娘L(fēng)險(xiǎn)將會增加,。（生物谷Bioon.com）

doi:10.1093/gerona/gls107
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Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer’s Disease: A 7-Year Follow-up

Cédric Annweiler1, Yves Rolland2, Anne M Schott3, Hubert Blain4, Bruno Vellas2, François R. Herrmann5 and Olivier Beauchet1

Background. Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older. Methods. Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer’s disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders. Results. Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98–0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08–0.67], p = .007). Conclusions. Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women.

doi:10.1093/gerona/gls136
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Low 25-Hydroxyvitamin D Predicts the Onset of Mobility Limitation and Disability in Community-Dwelling Older Adults: The Health ABC Study

Denise K. Houston1, Rebecca H. Neiberg2, Janet A. Tooze2, Dorothy B. Hausman3, Mary Ann Johnson3, Jane A. Cauley4, Doug C. Bauer5, M. Kyla Shea1, Gary G. Schwartz6, Jeff D. Williamson1, Tamara B. Harris7 and Stephen B Kritchevsky1 for the Health ABC StudyP>

Background. Although low 25-hydroxyvitamin D (25(OH)D) is prevalent among older adults and is associated with poor physical function, longitudinal studies examining vitamin D status and physical function are lacking. We examined the association between 25(OH)D, parathyroid hormone (PTH), and the onset of mobility limitation and disability over 6 years of follow-up in community-dwelling, initially well-functioning older adults participating in the Health, Aging and Body Composition study (n = 2,099). Methods. Serum 25(OH)D and PTH were measured at the 12-month follow-up visit (1998–1999). Mobility limitation and disability (any/severe difficulty walking 1/4 mile or climbing 10 steps) was assessed semiannually over 6 years of follow-up. The association between 25(OH)D, PTH, and mobility limitation and disability was examined using Cox proportional hazard regression models adjusted for demographics, season, behavioral characteristics, and chronic conditions. Results. At baseline, 28.9% of the participants had 25(OH)D <50 nmol/L and 36.1% had 25(OH)D of 50 to <75 nmol/L. Participants with 25(OH)D <50 and 50 to <75 nmol/L were at greater risk of developing mobility limitation (HR (95% CI): 1.29 (1.04–1.61) and 1.27 (1.05–1.53), respectively) and mobility disability (HR (95% CI): 1.93 (1.32–2.81) and 1.30 (0.92–1.83), respectively) over 6 years of follow-up compared with participants with 25(OH)D ≥75 nmol/L. Elevated PTH, however, was not significantly associated with developing mobility limitation or disability. Conclusions. Low 25(OH)D was associated with an increased risk of mobility limitation and disability in community-dwelling, initially well-functioning black and white older adults. Prevention or treatment of low 25(OH)D may provide a pathway for reducing the burden of mobility disability in older adults.