嚙齒類動物的社會隔離飼養(yǎng)已被證實能誘發(fā)成年動物的認(rèn)知和行為功能障礙,，因此常用于建立擬精神分裂癥的動物模型,。
但已有的研究工作所采用的社會隔離是從出生后21d至成年，應(yīng)激持續(xù)時間較長,，經(jīng)歷了幼年-成年早期-成年階段,，從而無法確定早期應(yīng)激誘發(fā)認(rèn)知障礙的“關(guān)鍵期”。而此關(guān)鍵期的確定對于進(jìn)一步研究精神疾病認(rèn)知障礙的發(fā)生,、發(fā)展機(jī)制,，以及隨后的腦區(qū)內(nèi)藥物注射等工作具有重要意義。
為觀察青少年階段社會隔離對成年大鼠潛伏抑制和內(nèi)側(cè)前額葉和伏隔核內(nèi)腦源性神經(jīng)營養(yǎng)因子水平的影響,，北京大學(xué)的邵楓所在課題組將成年大鼠于鼠齡38-51d時隔離飼養(yǎng),。隔離飼養(yǎng)干擾成年大鼠潛伏抑制，并顯著提高內(nèi)側(cè)前額葉內(nèi)的腦源性神經(jīng)營養(yǎng)因子水平,。實驗結(jié)果證實，青少年社會隔離是誘發(fā)神經(jīng)發(fā)育認(rèn)知障礙的“關(guān)鍵期”,，可用于建立神經(jīng)發(fā)育障礙疾病的動物模型,。
相關(guān)文章發(fā)表在《中國神經(jīng)再生研究（英文版）》雜志2013年4月第11期上。
生物谷推薦英文摘要：
Neural Regeneration Research DOI: 10.3969/j.issn.1673-5374.2013.11.008
Adolescent social isolation influences cognitive function in adult rats
Feng Shao, Xiao Han, Shuang Shao, Weiwen Wang
Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38–51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.
