2013年6月21日訊 /生物谷 Bioon.com/--虛擬的大腦圖譜如3D打印技術(shù)一直以來被神經(jīng)科學(xué)家譽(yù)為了解大腦的結(jié)構(gòu)和功能的有力工具,。日前研究人員利用3D打印技術(shù)首次建成人類大腦的3D模型,，顯示出了腦細(xì)胞結(jié)構(gòu)的細(xì)節(jié)。此超高分辨率圖譜,，被稱為“BigBrain”,，圖譜可以展示皮質(zhì)層細(xì)胞結(jié)構(gòu)甚至是腦神經(jīng)元之間微電流，這讓研究人員能夠了解到腦細(xì)胞之間的連接是如何產(chǎn)生復(fù)雜的行為,。這項(xiàng)技術(shù)是科學(xué)家經(jīng)過五年的努力，被視為神經(jīng)科學(xué)家必備的看家本領(lǐng),，有望加快這一領(lǐng)域的發(fā)展,。相關(guān)報(bào)道在6月21日《科學(xué)》雜志上報(bào)道,。
BigBrain圖譜集在揭示大腦結(jié)構(gòu)方面，分辨率是MRI掃描儀的50倍,。更重要的是,，它不需要核磁共振，也不將組織樣本放在顯微鏡玻片,，就能幫助研究人員,、醫(yī)生和藥物開發(fā)研究人員，在檢測(cè)人的大腦,。（生物谷 Bioon.com）
生物谷推薦的英文文章
Science DOI: 10.1126/science.1235381
BigBrain: An Ultrahigh-Resolution 3D Human Brain Model
Katrin Amunts, laude Lepage, Louis Borgeat, Hartmut Mohlberg, Timo Dickscheid, Marc-Étienne Rousseau, Sebastian Bludau, Pierre-Louis Bazin, Lindsay B. Lewis, Ana-Maria Oros-Peusquens, Nadim J. Shah, Thomas Lippert, Karl Zilles, Alan C. Evans
Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. “BigBrain” is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.
