導語：令人不安的研究進步帶來的神經倫理問題，美國倫理委員會組織稱將嚴格把控腦項目(BRAIN)涉及的倫理道德問題,。
7月份,，小鼠虛假記憶的植入實驗，最近讓倫理學家坐立不安,。這項研究由麻省理工大學Susumu Tonegawa和他的同事進行,，他們通過刺激小鼠海馬中的神經元，造成老鼠收到發(fā)生在腳刺激的一個虛假信息,。Susumu Tonegawa稱并沒有打算進入人體,，只是為了研究記憶的形成。
但這項實驗卻驚動了神經倫理學家,，“這項實驗可能帶來示范效應,，會向人們灌輸這種理念：通過控制大腦來左右他人的思想”，華盛頓喬治敦大學神經倫理學主任James Giordano說,，這項研究將會激起許多倫理學問題,。
8月20日，美國總統(tǒng)奧巴馬的生物倫理委員會將在賓夕法尼亞州,，費城舉行會議,，會議主要討論構建一套道德標準，以指導大腦項目(BRAIN),。目前美國研究機構審查委員會已有一套倫理監(jiān)督機制,，任何涉及人類受試者的研究必須經過他們的倫理認證才予以通過。（生物谷 Bioon.com）
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Science：記憶的移植——美成功在小鼠大腦植入虛假記憶
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The false mouse memories made the ethicists uneasy. By stimulating certain neurons in the hippocampus, Susumu Tonegawa and his colleagues caused mice to recall receiving foot shocks in a setting in which none had occurred1. Tonegawa, a neuroscientist at the Massachusetts Institute of Technology in Cambridge, says that he has no plans to ever implant false memories into humans — the study, published last month, was designed just to offer insight into memory formation.
But the experiment has nonetheless alarmed some neuroethicists. “That was a bell-ringer, the idea that you can manipulate the brain to control the mind,” says James Giordano, chief of neuroethics studies at Georgetown University in Washington DC. He says that the study is one of many raising ethical concerns, and more are sure to come as an ambitious, multi-year US effort to parse the human brain gets under way.
The BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative will develop technologies to understand how the brain’s billions of neurons work together to produce thought, emotion, movement and memory. But, along with the discoveries, it could force scientists and society to grapple with a laundry list of ethical issues: the responsible use of cognitive-enhancement devices, the protection of personal neural data, the prediction of untreatable neurodegenerative diseases and the assessment of criminal responsibility through brain scanning.
On 20 August, US President Barack Obama’s commission on bioethics will hold a meeting in Philadelphia, Pennsylvania, to begin to craft a set of ethics standards to guide the BRAIN project. There is already one major mechanism for ethical oversight in US research: institutional review boards, which must approve any studies involving human subjects. But many ethicists say that as neuroscience discoveries creep beyond laboratory walls into the marketplace and the courtroom, more comprehensive oversight is needed. “The long-term consequences of more brain knowledge — whether it’s good for an ethnic group or threatens your personal identity — there’s sort of no one in charge of that,” says Arthur Caplan, director of medical ethics at New York University’s Langone Medical Center.
Tonegawa’s study adds to the growing evidence that memories are surprisingly pliable. In the past few years, researchers have shown that drugs can erase fearful memories2 or disrupt alcoholic cravings in rodents3. Some scientists have even shown that they can introduce rudimentary forms of learning during sleep in humans4. Giordano says that dystopian fears of complete human mind control are overblown. But more limited manipulations may not be far off: the US Defense Advanced Research Projects Agency (DARPA), one of three government partners in the BRAIN Initiative, is working towards ‘memory prosthetic’ devices to help soldiers with brain injuries to regain lost cognitive skills.
Deep brain stimulation (DBS), in which implants deliver simple electrical pulses, is another area that concerns neuroethicists. The devices have been used since the 1990s to treat motor disorders such as Parkinson’s disease, and are now being tested in patients with psychiatric conditions such as obsessive–compulsive disorder and major depression. Giordano says that applying DBS technology more widely requires ethical care. “We’re dealing with things affecting thought, emotion, behaviour — what people hold valuable as the essence of the self,”he says.
Neuroethicists are noticing challenges beyond the medical system, too, particularly in the courtroom. Judy Illes, a neurology researcher at the University of British Columbia in Vancouver, Canada, and co-founder of the International Neuroethics Society, says that brain imaging could affect the criminal-justice system by changing definitions of personal responsibility. Patterns of brain activity have already been used in some courtrooms to assess the mental fitness of the accused. Some ethicists worry that an advanced ability to map human brain function might be used to measure an individual’s propensity for violent or aberrant behaviour — or even, one day, to predict it.
At next week’s meeting, the presidential commission will hear from each of the US agencies involved in the BRAIN Initiative — DARPA, the National Institutes of Health and the National Science Foundation — about preliminary scientific plans and anticipated ethical issues. Lisa Lee, the commission’s executive director, says that the group plans to discuss broad ethical concerns for human and animal participants in neuroscience research, and also the societal implications of discoveries that could arise from the BRAIN Initiative. Although no specific timeline has been set, the commission typically holds three to four meetings over a period of up to 18 months, culminating in recommendations to the President.
As neuroethicists wade into the issues, they may look to the precedent set by the Human Genome Project’s Ethical, Legal and Social Implications (ELSI) research programme, which has provided about US$300 million in study support over 23 years. The programme raised the profile of genetic privacy issues and laid the foundations for the Genetic Information Nondiscrimination Act of 2008, which prohibits discrimination by employers and health insurers on the basis of genetic information.
Thomas Murray, one of the architects of ELSI and president emeritus of the Hastings Center, a bioethics research institute in Garrison, New York, is among the speakers invited to the commission meeting. He considers the BRAIN Initiative a timely opportunity to develop an ELSI programme for neuroscience. “There will be wonderful questions about human responsibility, human agency,” he says. “It’s never too soon to begin.”
