Toll樣受體 (Toll-like receptors，TLRs) 是進(jìn)化中比較保守的一個(gè)受體家族, 至少包括10個(gè)成員. TLRs能特異地識(shí)別病原相關(guān)的分子模式 (PAMPs),，不僅在激活天然免疫中發(fā)揮重要的作用,，而且還調(diào)節(jié)獲得性免疫，是連接天然免疫和獲得性免疫的橋梁. 近年來(lái),，TLRs信號(hào)轉(zhuǎn)導(dǎo)的研究,，特別是在負(fù)調(diào)控研究領(lǐng)域，進(jìn)展非常迅速. 對(duì)TLRs信號(hào)通路新進(jìn)展以及TLRs在抗感染免疫中的作用進(jìn)行了綜述.
英文摘要：
Toll-like receptors (TLRs), a large family consisting of at least 10 members, are evolutionarily conserved to recognize pathogen-associated molecular patterns (PAMPs). TLRs activation not only initiates innate immunity, but also regulates enhance antigen-specific acquired immunity, and thus associates innate and adaptive immunity. In recent years, studies on the TLRs signaling, especially their negative regulation, rapidly progressed. TLRs signaling pathway and their roles in regulating immune responses against invading pathogens were reviewed.
