杰斐遜醫(yī)學院的科學家發(fā)現(xiàn),，狂犬病可能握有對抗艾滋病的鑰匙。研究人員利用減毒的狂犬病病毒,，運送與艾滋病有關的蛋白質到動物體內,，而使牠們接種后，可以對抗艾滋病,。
研究作者Matthias Schnell教授將二種功能不同的病毒蛋白質,，插入狂犬病病毒染色體,，并利用這樣的病毒疫苗防止恒河猴發(fā)病,。
其中一種蛋白質是HIV表面的糖蛋白，而另一種是猴免疫缺陷病毒（Simian Immunodeficiency Virus, SIV）內部的蛋白質,。之所以使用SIV,，是因為HIV不會導致猴子發(fā)生艾滋病。
科學家的想法是,，狂犬病疫苗可以導致動物的免疫系統(tǒng)發(fā)生強烈的反應,，因此研究人員希望了解以狂犬病疫苗對抗HIV 和相關疾病的安全性和效果。
科學家表示,，在經過最初的接種二年后,，四只接受接種的非人類之靈長類在注射了病毒后,，獲得保護而未感染疾病。而控制組的二只動物,，則發(fā)生了類似艾滋病的疾病,。這篇研究發(fā)表于2007 年4月1 日的Journal of Infectious Diseases中。
(資料來源 : Bio.com)
部分英文原文：
Journal of Infectious Diseases
Volume 195(2007), pages 980 - 988
DOI: 10.1086/512243
Highly Attenuated Rabies VirusBased Vaccine Vectors Expressing Simian-Human Immunodeficiency Virus89.6P Env and Simian Immunodeficiency Virusmac239 Gag Are Safe in Rhesus Macaques and Protect from an AIDS-Like Disease
Philip M. McKenna, Martin L. Koser, Kevin R. Carlson, David C. Montefiori, Norman L. Letvin, Amy B. Papaneri, Roger J. Pomerantz, Bernhard Dietzschold, Peter Silvera, James P. McGettigan, and Matthias J. Schnell
Abstract
We analyzed the safety and immunogenicity of attenuated rabies virus vectors expressing simian-human immunodeficiency virus (SHIV)189.6P Env or simian immunodeficiency virus (SIV)mac239 Gag in rhesus macaques. Four test macaques were immunized with both vaccine constructs, and 2 control macaques received an empty rabies vector. Seroconversion against rabies virus glycoprotein (G) and SHIV89.6P Env was detected after the initial immunization, but no cellular responses against SHIV antigens were observed. HIV/SIV-specific immune responses were not enhanced by boosts with the same vectors. Therefore, we constructed vectors expressing SHIV89.6P Env and SIVmac239 Gag in which the rabies G was replaced with the G protein of vesicular stomatitis virus (VSV). Two years after initial immunization, a boost with the rabiesVSV G vectors resulted in SIV/HIV-specific immune responses. Upon challenge with SHIV89.6P test macaques controlled the infection, whereas control macaques had high levels of viremia and a profound loss of CD4+ T cells, with 1 control macaque dying of an AIDS-like disease.
