康奈爾大學(xué)的研究人員發(fā)現(xiàn)，胎兒在子宮中或是嬰兒暴露于環(huán)境毒素或藥物,，所造成的后天疾病,，有共同的免疫模式。

    在這篇發(fā)表于Current Medicinal Chemistry中的研究報(bào)告里,，康奈爾大學(xué)獸醫(yī)系的教授Rodney Dietert,，和Performance Plus Consulting 的Janice Dietert，發(fā)現(xiàn)所有與發(fā)育免疫毒性有關(guān)的慢性疾病,，都與相同的類(lèi)型的免疫損傷有關(guān),。

    這些與發(fā)育免疫毒性有關(guān)的疾病包括哮喘、過(guò)敏,、對(duì)疫苗抑制反應(yīng),、對(duì)感染的易感性增加、兒童的神經(jīng)行為疾病,、自體免疫疾病,、癌癥、腦性痲痹,、動(dòng)脈粥樣硬化,、高血壓和男性不孕癥。

    他們發(fā)現(xiàn)大部分的疾病有二個(gè)現(xiàn)象是一樣的：與不平衡的免疫系統(tǒng)有關(guān),，以及過(guò)大的發(fā)炎反應(yīng)(細(xì)胞層級(jí)),。

    當(dāng)胎兒或嬰兒受到發(fā)育免疫毒性影響時(shí)，二種免疫過(guò)程：T 幫手(Th) 細(xì)胞的平衡和樹(shù)狀細(xì)胞成熟性,，都會(huì)受到破壞而擾亂發(fā)炎細(xì)胞的功能之調(diào)控,，導(dǎo)致過(guò)大的發(fā)炎反應(yīng)。

（編譯/姜欣慧） (資料來(lái)源 : biocompare)

英文原文鏈接：

http://news.biocompare.com/newsstory.asp?id=181070

原始出處：

Early-Life Immune Insult and Developmental Immunotoxicity (DIT)-Associated Diseases: Potential of Herbal- and Fungal-Derived Medicinals

Authors: Dietert, Rodney R.1; Dietert, Janice M.1

Source: Current Medicinal Chemistry, Volume 14, Number 10, April 2007, pp. 1075-1085(11)

Publisher: Bentham Science Publishers

Abstract:

Developmental immunotoxicity (DIT) is increasingly recognized as a significant risk factor contributing to later life immune dysfunction as well chronic disease. In fact, recent increases in the incidence of asthma, allergic disease, autoimmunity and childhood infections maybe linked to problematic early life environmental exposures. The immune system of the non-adult is particularly susceptible to environmental influences whether from prenatal exposure to environmental toxins, maternallyadministered drugs, infections or from postnatal exposure to toxicants, infectious agents and allergens. Additionally, adultexposure models of immunotoxicity have been largely ineffective in predicting DIT risk. DIT-induced immune dysfunction can take many forms depending upon the environmental factor(s) involved and the precise developmental timing of exposure. If one examines the spectrum of published studies, a predominant phenotype has emerged that includes: Th balance skewing toward Th2, suppression of Th1 function, regulatory T cell function alteration, T cell repertoire abnormalities, problematic regulation of inflammatory cell function leading to hyperinflammatory responses and perturbation of cytokine networks. Early-life immune insult can also result in damage to the neurological and cardiovascular systems as well as endocrine and reproductive organs. Most therapeutic approaches to date have addressed the disease outcomes of DIT (e.g. asthma, allergy, autoimmunity, infections, and cancer) rather than focusing on the underlying immune dysfunction that creates the increased disease risk. While identification and prevention of problematic early life exposures is the best protection against DIT, this is not always possible. Therefore, identification of potential therapeutic approaches to reverse the immune dysfunction in the juvenile or adult is needed. In this review, we consider potential phytotherapeutic candidates among herbal- and fungal-derived medicinals for possible postnatal correction of the most predominant DIT-induced immune problems.
Keywords: Developmental immunotoxicity (DIT); immunosuppression; chronic disease; phytotherapy; herbal; asthma; allergy; autoimmunity

Document Type: Research article

DOI: 10.2174/092986707780362899

Affiliations: 1: Department of Microbiology and Immunology, College of Veterinary Medicine, C5-135 VMC, Cornell University,Ithaca, NY 14853 USA.