生物谷報(bào)道：德國的一項(xiàng)最新研究顯示,，2周歲以下的孩子與貓接觸得越多,，就越容易對(duì)貓產(chǎn)生過敏癥狀,。但這種過敏癥狀會(huì)在孩子6歲以后逐漸消失,。
德國國立環(huán)境與健康研究中心的Joachim Heinrich博士的研究小組針對(duì)2166名從新生兒到6周歲不等的孩子進(jìn)行這項(xiàng)研究,。該研究小組發(fā)現(xiàn),，在孩子3個(gè)月大時(shí),，家里灰塵中貓過敏源越多，孩子到2歲時(shí)出現(xiàn)貓過敏癥狀的可能性就越大,。
但是孩子不會(huì)終身罹患這種貓過敏癥狀,。到6歲以后，接觸貓過敏源的孩子都不再發(fā)生任何過敏反應(yīng)或相關(guān)疾病了,。
研究還發(fā)現(xiàn),，那些家里不養(yǎng)貓，但經(jīng)常和動(dòng)物接觸的孩子特別容易患上過敏,，如果父母有過敏癥狀的話,，這種機(jī)率又會(huì)更高了。
本篇研究報(bào)告發(fā)表于2007年5月的Journal of Allergy and Clinical Immunology中,。
(資料來源 : Reuters)
原始出處:
Journal of Allergy and Clinical Immunology
Volume 119, Issue 5, Pages 1148-1155 (May 2007)
Longitudinal study on cat allergen exposure and the development of allergy in young children
Chih-Mei Chen, MScab, Peter Rzehak, PhDab, Anne Zutavern, MDac, Bärbel Fahlbusch, PhDd, Wolfgang Bischof, MDe, Olf Herbarth, PhDf, Michael Borte, MD, PhDgh, Irina Lehmann, PhDi, Heidrun Behrendt, MDj, Ursula Krämer, PhDk, H.-Erich Wichmann, MD, PhDab, Joachim Heinrich, PhDa</FORM>-->
Received 5 December 2006; received in revised form 24 January 2007; accepted 9 February 2007 published online 13 April 2007.
Neuherberg, Munich, Jena, Leipzig, and Düsseldorf, Germany
Background
The influence of cat allergen exposure in early childhood on the development of sensitization and allergic diseases is complex. Little is known about the natural course of the sensitization development within individuals.
Objective
We investigated the association between cat allergen exposure in infancy and cat ownership and cat contact during childhood and the development of cat sensitization and allergic diseases up to age 6 years using a longitudinal analysis approach.
Methods
Overall, 2166 children from an ongoing birth cohort study were included in the analysis. House dust samples were collected 3 months after birth. Cat allergen levels were extracted. Blood samples were collected when the children were 2 and 6 years old. Information on the allergic symptoms of children and doctor-diagnosed allergic disease were collected at each follow-up using questionnaires.
Results
Cat allergen exposure in infancy was positively associated with sensitization at age 2 years but not at age 6 years. No associations existed between cat allergen exposure in infancy and allergic symptoms and diseases up to age 6 years. Cumulative allergen exposure from cat ownership and regular cat contact increased the risk of cat sensitization up to age 6 years.
Conclusion
Cat allergen exposure in infancy increases the risk of sensitization development in early childhood but not in school-age children. Cumulative allergen exposure from cat ownership and regular cat contact during childhood contribute to sensitization development up to school age.
Clinical implications
Cat allergen avoidance at home alone might be not effective to prevent the development of allergic sensitization in young children.
Key words: Allergy, cats, children, cohort study, house dust, ownership, sensitization
