生物谷報道：病毒編碼的miRNA已被發(fā)現(xiàn)存在于皰疹病毒屬中,，但是關(guān)于它們的生物學(xué)功能并不清楚。發(fā)表于最新一期《科學(xué)》雜志上的一篇研究報告,，科研人員最近研究出一種新的算法可用于預(yù)測miRNA的靶標(biāo),，并將其運用于人細(xì)胞巨化病毒miRNA上，從而鑒定出編碼1型主要組織相容性復(fù)合物的B鏈（MICB）的基因可能是hcmv-miR-UL112的一個潛在的靶標(biāo),。
MICB是NK細(xì)胞活化受體NKG2D的配基,，可在應(yīng)激作用下與NKG2D作用，它對NK細(xì)胞對病毒感染細(xì)胞和腫瘤細(xì)胞的殺傷作用的有效發(fā)揮具有重要的作用,。這項研究的結(jié)果顯示,，在病毒感染過程中，hcmv-miR-UL112可以特異地下調(diào)MICB的表達(dá),，導(dǎo)致其與NKG2D的結(jié)合下降,，從而減弱了NK細(xì)胞的殺傷作用。
這項研究揭示了一種新的免疫逃避的機(jī)制,，這種建立在miRNA基礎(chǔ)上的機(jī)制被認(rèn)為可能在人巨細(xì)胞病毒感染的過程中起作用,。
作者簡介：
Ofer Mandelboim
Lautenberg Center for General and Tumor Immunology
Hebrew University-Hadassah Medical School
原文出處：
Host Immune System Gene Targeting by a Viral miRNA
Noam Stern-Ginossar, Naama Elefant, Albert Zimmermann, Dana G. Wolf, Nivin Saleh, Moshe Biton, Elad Horwitz, Zafnat Prokocimer, Mark Prichard, Gabriele Hahn, Debra Goldman-Wohl, Caryn Greenfield, Simcha Yagel, Hartmut Hengel, Yael Altuvia, Hanah Margalit, and Ofer Mandelboim
Science 20 July 2007: 376-381.
Cytomegalovirus aids its own survival by encoding a microRNA that inhibits, in the infected host cell, translation of a ligand that would normally trigger antiviral responses.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
相關(guān)基因：
MICB
Official Symbol MICB and Name: MHC class I polypeptide-related sequence B [Homo sapiens]
Other Aliases: DAQB-72H16.3, PERB11.2
Other Designations: MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I molecule; MHC class I-like molecule PERB11.2-IMX; OTTHUMP00000035091; OTTHUMP00000035588; stress inducible class I homolog
Chromosome: 6; Location: 6p21.3
Annotation: Chromosome 6, NC_000006.10 (31573945..31586880)
MIM: 602436
GeneID: 4277
KLRK1
Official Symbol KLRK1 and Name: killer cell lectin-like receptor subfamily K, member 1 [Homo sapiens]
Other Aliases: CD314, D12S2489E, KLR, NKG2-D, NKG2D
Other Designations: NK cell receptor D; NKG2-D type II integral membrane protein
Chromosome: 12; Location: 12p13.2-p12.3
Annotation: Chromosome 12, NC_000012.10 (10416219..10451632, complement)
GeneID: 22914
