生物谷報道：研究人員在9月在線出版的《自然—免疫學(xué)》期刊上報告：血液干細(xì)胞在神經(jīng)細(xì)胞信號的作用下會被激活,。
Tsvee Lapidot和同事在實(shí)驗中發(fā)現(xiàn)，骨髓干細(xì)胞表達(dá)出了多巴胺受體,。在壓力狀態(tài)下釋放的神經(jīng)傳遞素能誘發(fā)血細(xì)胞分化,，并從保護(hù)它們的骨髓環(huán)境中遷移出來,。用多巴胺或其他神經(jīng)傳遞素對小鼠進(jìn)行治療，會導(dǎo)致小鼠骨髓和血液循環(huán)中的干細(xì)胞數(shù)量的增加,。同樣地,，刺激人體骨髓細(xì)胞中的神經(jīng)傳遞素也能增加它們移植到“人源化鼠”中的可能性，這種“人源化鼠”的免疫系統(tǒng)用人體細(xì)胞進(jìn)行了重組,。
對于需要骨髓移植的治療來說,，新發(fā)現(xiàn)可用于提高治療效率的研究。（科學(xué)時報）
原始出處:
Nature Immunology
Published online: 9 September 2007 | doi:10.1038/ni1509
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
Asaf Spiegel1, Shoham Shivtiel1, Alexander Kalinkovich1, Aya Ludin1, Neta Netzer1, Polina Goichberg1, Yaara Azaria1, Igor Resnick2, Izhar Hardan3, Herzel Ben-Hur4, Arnon Nagler3, Menachem Rubinstein5 & Tsvee Lapidot1
Abstract
Catecholamines are important regulators of homeostasis, yet their functions in hematopoiesis are poorly understood. Here we report that immature human CD34+ cells dynamically expressed dopamine and 2-adrenergic receptors, with higher expression in the primitive CD34+CD38lo population. The myeloid cytokines G-CSF and GM-CSF upregulated neuronal receptor expression on immature CD34+ cells. Treatment with neurotransmitters increased the motility, proliferation and colony formation of human progenitor cells, correlating with increased polarity, expression of the metalloproteinase MT1-MMP and activity of the metalloproteinase MMP-2. Treatment with catecholamines enhanced human CD34+ cell engraftment of NOD-SCID mice through Wnt signaling activation and increased cell mobilization and bone marrow Sca-1+c-Kit+Lin- cell numbers. Our results identify new functions for neurotransmitters and myeloid cytokines in the direct regulation of human and mouse progenitor cell migration and development.
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Department of Hematology & Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Assaf Haroffe Medical Center, Tsrifin 70300, Israel.
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.
Correspondence to: Tsvee Lapidot1 e-mail: [email protected]
