銜接蛋白STING（它是“Stimulator of INterferon Genes”的首字母縮寫,，亦稱MITA和ERIS）正在成為先天免疫系統(tǒng)對微生物DNA的反應(yīng)當(dāng)中的一個重要組成部分。
Ishikawa等人發(fā)現(xiàn),，在沒有STING時,，小鼠對幾種DNA 和 RNA病毒感染的敏感度得到增強。由STING調(diào)節(jié)的干擾素誘導(dǎo),，要求STING將“TANK-結(jié)合激酶-1”從內(nèi)質(zhì)網(wǎng)向含有內(nèi)體囊的Sec5重新定位,。這項工作說明，STING可能是宿主抵抗單純皰疹病毒等DNA病原體所必需的,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature 461, 788-792 (8 October 2009) | doi:10.1038/nature08476
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa1, Zhe Ma1 & Glen N. Barber1
1 Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Correspondence to: Glen N. Barber1 Correspondence and requests for materials should be addressed to G.N.B.
The innate immune system is critical for the early detection of invading pathogens and for initiating cellular host defence countermeasures, which include the production of type I interferon (IFN)1, 2, 3. However, little is known about how the innate immune system is galvanized to respond to DNA-based microbes. Here we show that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection4. Murine embryonic fibroblasts, as well as antigen presenting cells such as macrophages and dendritic cells (exposed to intracellular B-form DNA, the DNA virus herpes simplex virus 1 (HSV-1) or bacteria Listeria monocytogenes), were found to require STING to initiate effective IFN production. Accordingly, Sting-knockout mice were susceptible to lethal infection after exposure to HSV-1. The importance of STING in facilitating DNA-mediated innate immune responses was further evident because cytotoxic T-cell responses induced by plasmid DNA vaccination were reduced in Sting-deficient animals. In the presence of intracellular DNA, STING relocalized with TANK-binding kinase 1 (TBK1) from the endoplasmic reticulum to perinuclear vesicles containing the exocyst component Sec5 (also known as EXOC2). Collectively, our studies indicate that STING is essential for host defence against DNA pathogens such as HSV-1 and facilitates the adjuvant activity of DNA-based vaccines.
