美國研究人員最新發(fā)明一種粘貼式免疫法,。這種方法有望取代注射式免疫，使免疫預(yù)防更加安全和便捷,。
美國佐治亞理工學(xué)院的科研人員7月18日在《自然－醫(yī)學(xué)》(Nature Medicine)雜志網(wǎng)絡(luò)版上報告說,，粘貼式免疫法在實驗鼠身上的試驗已取得成功。
研究人員解釋說,，粘貼式免疫法是指在皮膚上貼上一塊膏藥,，膏藥里有直徑不到1毫米的“超微針”，這些含有免疫藥物的“超微針”會緩慢溶解滲入皮膚,。整個“注射”過程需要5至15分鐘,，不會導(dǎo)致流血和疼痛。
研究負責(zé)人薩里萬說,，一旦粘貼式免疫法人體試驗成功,，傳統(tǒng)的注射式免疫法或?qū)⒈蝗〈脮r,，如要預(yù)防流感,，人們只需到藥店買一塊膏藥，自己往身上一貼即可,。(生物谷Bioon.com)
>>>借著上海世博會的良好契機,，"第一屆腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)國際研討會"將于2010年10月12日在中國上海盛大開幕，這將為廣大活躍在腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)第一線的科研工作者提供一個互動交流的平臺,。
會議官方網(wǎng)站：www.cancerasia.org
生物谷推薦原文出處：
Nature Medicine doi:10.1038/nm.2182
Dissolving polymer microneedle patches for influenza vaccination
Sean P Sullivan1,4, Dimitrios G Koutsonanos2,4, Maria del Pilar Martin2, Jeong Woo Lee3, Vladimir Zarnitsyn3, Seong-O Choi3, Niren Murthy1, Richard W Compans2, Ioanna Skountzou2 & Mark R Prausnitz1,3
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.
