不少飲酒過度的人都有抗病能力變?nèi)醯母杏X,。英國學(xué)術(shù)刊物日前發(fā)表的一項新研究成果顯示,，長期攝入大量酒精會從兩方面影響免疫力：使體內(nèi)某些抗病毒物質(zhì)含量下降；一些易引起發(fā)炎的物質(zhì)含量隨之上升,。
新一期英國《BMC免疫學(xué)》雜志刊登的報告說,，美國馬薩諸塞大學(xué)醫(yī)學(xué)院的研究人員進行了相關(guān)實驗。他們從一些健康志愿者體內(nèi)提取組織樣本,，然后用酒精進行處理,，其效果大概相當(dāng)于一個人每天攝入60克酒精且持續(xù)一個星期。
研究結(jié)果顯示,，在組織樣本中,，一些與免疫力有關(guān)的物質(zhì)含量隨之發(fā)生變化，其中有助于抵抗病毒感染的干擾素（IFN）含量下降,，而另一種名為“α型腫瘤壞死因子”（TNF α）的促炎癥物質(zhì)含量會增多,。
參加該研究的真吉·紹博教授說，酒精通過這兩方面作用削弱人體免疫力,，長期過度飲酒就會導(dǎo)致對許多疾病的抵抗力下降,，如抵抗丙型肝炎病毒感染的能力會降低。因此為了保持身體健康，喜歡飲酒者應(yīng)注意適度飲酒,。（生物谷 Bioon.com）
doi:10.1186/1471-2172-12-55
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Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, Gyongyi Szabo
Prolonged alcohol consumption is a significant co-factor in the progression of chronic viral infections including hepatitis C and HIV, which are both single-stranded RNA viruses. Toll like receptor 8 (TLR8), a pattern recognition receptor expressed in monocytes, senses viral single stranded RNA as a danger signal and leads to the induction of Type I interferon (IFN) as well as the pro-inflammatory cytokine, tumor necrosis factor alpha (TNF alpha). Lipopolysaccharide (LPS), a Toll like receptor 4 (TLR4) ligand, was shown to affect inflammatory cell activation after alcohol consumption and in HIV and HCV infections. Here we hypothesized that alcohol exposure modulates TLR8- and TLR4-ligand-induced monocyte activation and affects both type I IFN and inflammatory cytokine induction.
