10月21日,，國(guó)際著名免疫學(xué)雜志Immunological Reviews在線(xiàn)發(fā)表了美國(guó)芝加哥大學(xué),、中科院生物物理所“千人計(jì)劃”傅陽(yáng)心教授和生物物理所“百人計(jì)劃”朱明昭研究員聯(lián)合署名的特邀綜述文章The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling,。
淋巴結(jié)是機(jī)體的主要淋巴器官之一,，幾乎遍布全身各處,，是監(jiān)視病原入侵等機(jī)體異常變化,、過(guò)濾清除病原微生物,、誘導(dǎo)抗原特異性免疫應(yīng)答發(fā)生的重要場(chǎng)所,，也是腫瘤轉(zhuǎn)移的主要途徑之一。盡管淋巴結(jié)的發(fā)育與生俱來(lái),，但是它們的形態(tài)和結(jié)構(gòu)具有較強(qiáng)的可塑性,。在正常生理狀態(tài)下，淋巴結(jié)維持較穩(wěn)定的形態(tài)和結(jié)構(gòu),；然而在病理狀態(tài)（感染,、炎癥和腫瘤）下，淋巴結(jié)的形態(tài)和結(jié)構(gòu)可能發(fā)生顯著的重塑變化,。淋巴結(jié)的這種穩(wěn)態(tài)平衡和重塑變化是其功能發(fā)揮的重要基礎(chǔ),，也體現(xiàn)了其對(duì)免疫應(yīng)答等功能的高度精細(xì)控制。在這些過(guò)程中,，各種固有免疫細(xì)胞,、獲得性免疫細(xì)胞、基質(zhì)細(xì)胞、細(xì)胞因子,、病原微生物,，在時(shí)間和空間上，動(dòng)態(tài)的,、有序的相互作用,，構(gòu)成了淋巴結(jié)穩(wěn)態(tài)平衡和重塑變化以及功能發(fā)揮的細(xì)胞和分子基礎(chǔ)。正是這種多細(xì)胞,、多因子參與的時(shí)空運(yùn)動(dòng)的復(fù)雜性以及淋巴結(jié)在免疫系統(tǒng)中的重要地位,，決定了關(guān)于淋巴結(jié)的形態(tài)和結(jié)構(gòu)變化以及功能研究一直是免疫學(xué)領(lǐng)域中具有挑戰(zhàn)性的重要和前沿方向。
Immunological Reviews是國(guó)際著名的免疫學(xué)領(lǐng)域綜述型期刊,。圍繞當(dāng)前免疫學(xué)的重要主題,，該雜志邀請(qǐng)?jiān)谀骋恢黝}方向做出過(guò)重要貢獻(xiàn)的國(guó)際知名學(xué)者，結(jié)合自己的研究工作,，撰寫(xiě)綜述文章,。朱明昭研究員和傅陽(yáng)心教授長(zhǎng)期合作，致力于胸腺,、淋巴結(jié)等淋巴器官結(jié)構(gòu),、發(fā)育和功能等方面的研究，在該領(lǐng)域取得了一系列高水平的研究成果,，也得到了國(guó)際同行的高度認(rèn)可,，多次在國(guó)際高水平雜志上發(fā)表研究論文和綜述文章。
雙方最近的合作研究表明,，TNF家族核心分子LIGHT在炎癥過(guò)程中的淋巴結(jié)重塑變化中發(fā)揮重要作用,。LIGHT分子參與調(diào)節(jié)了炎癥因子、趨化因子和粘附分子等的表達(dá),，從而進(jìn)一步影響了樹(shù)突狀細(xì)胞和淋巴細(xì)胞從外周向淋巴結(jié)的遷移和免疫應(yīng)答（該研究結(jié)果已于今年6月份發(fā)表于Journal of Immunology ）,。
在此次發(fā)表的這篇綜述文章中，朱明昭研究員和傅陽(yáng)心教授結(jié)合自己長(zhǎng)期以來(lái)的研究結(jié)果和經(jīng)驗(yàn),，對(duì)TNF家族核心分子LIGHT,、TNF和淋巴毒素在淋巴結(jié)穩(wěn)態(tài)平衡和重塑變化中的分子作用機(jī)理、細(xì)胞相互作用基礎(chǔ)及其生理病理意義進(jìn)行了較全面的總結(jié),、分析,、討論和展望，對(duì)于促進(jìn)該領(lǐng)域的進(jìn)一步發(fā)展,，具有重要的指導(dǎo)和推動(dòng)意義,。
相關(guān)研究得到國(guó)家自然科學(xué)基金委、科技部和中國(guó)科學(xué)院的資助,。(生物谷 Bioon.com)
doi:10.1111/j.1600-065X.2011.01061.x
PMC:
PMID:
The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling
Mingzhao Zhu, Yang-Xin Fu
Summary: Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases have not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.
