生物工程學(xué)報  25 June 2009, 25(6):909～913

基于微生物的可控生物制造

史續(xù)典, 王剛, 王大明, 余龍江, 楊光

華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院 國家納米藥物工程技術(shù)中心, 武漢 430074

摘  要: 微生物種類豐富, 尺寸涵蓋納米與微米級, 是天然的可用于納米,、微米及多層次跨尺度加工的"基本單元"。目前的生物制造方法大多不適用于微生物活細(xì)胞, 無法發(fā)揮其整體的生物學(xué)功能及優(yōu)勢。本研究探索并建立了微流控和磁控的可用于微生物活體的微納米生物制造新方法, 定位操縱和有序排列微生物活體。以微生物為微納米機器人, 誘發(fā)其特有的生物學(xué)功能, 進(jìn)行受控自組裝等生物制造過程, 由此有望設(shè)計和創(chuàng)制一系列新型特殊功能材料和器件。

關(guān)鍵詞: 微納生物制造, 微流控技術(shù), 磁控微生物, 細(xì)菌纖維素, 仿生礦化

Controllable bio-fabrication based on microbes

Xudian Shi, Gang Wang, Daming Wang, Longjiang Yu, and Guang Yang

National Engineering Research Center for Nano-Medicine, College of Life Science & Technology, Huazhong University of Science & Technology Wuhan 430074, China

Abstract: Microorganisms in nature have rich variety, whose sizes are from nano scale to micro scale. Therefore, microbes can be used as natural "building blocks" in nano/micro multi-level fabrication processes. At present, most of the bio-manufacturing methods do not apply to direct control of living microbes. Their microbiological global functions and superiorities are not available. In this paper, two novel nano/micro bio-fabrication approaches, micro-fluidic control method and magnetic control method have been established. The living microbes could be manipulated to form micro-scaled patterns or to move orientedly. By these approaches, living microbes are taken as nano/micro robots. We could employ their specific biological functions and regulate their controllable self-assembly, which is expected to design and create a series of new special functional materials and devices.

Keywords: nano/micro bio-fabrication, micro-fluidic technique, magnetic controllable microbes, bacterial cellulose, biomimetic mineralization

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